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Science 318 (5852): 926-927

Copyright © 2007 by the American Association for the Advancement of Science

mTOR, Unleashed

Christopher G. Proud

A mitochondrial membrane protein links two parts of a signaling pathway that is central to cell growth and proliferation.

The author is in the Department of Biochemistry and Molecular Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.

Therapeutic Targeting of Autophagy in Disease: Biology and Pharmacology.
Y. Cheng, X. Ren, W. N. Hait, and J.-M. Yang (2013)
Pharmacol. Rev. 65, 1162-1197
   Abstract »    Full Text »    PDF »
miRNA Analysis for the Assessment of Exercise and Amino Acid Effects on Human Skeletal Muscle.
S. M. Pasiakos and J. P. McClung (2013)
Adv Nutr 4, 412-417
   Abstract »    Full Text »    PDF »
Intermittent Bolus Feeding Has a Greater Stimulatory Effect on Protein Synthesis in Skeletal Muscle Than Continuous Feeding in Neonatal Pigs.
M. C. Gazzaneo, A. Suryawan, R. A. Orellana, R. M. Torrazza, S. W. El-Kadi, F. A. Wilson, S. R. Kimball, N. Srivastava, H. V. Nguyen, M. L. Fiorotto, et al. (2011)
J. Nutr. 141, 2152-2158
   Abstract »    Full Text »    PDF »
The abundance and activation of mTORC1 regulators in skeletal muscle of neonatal pigs are modulated by insulin, amino acids, and age.
A. Suryawan and T. A. Davis (2010)
J Appl Physiol 109, 1448-1454
   Abstract »    Full Text »    PDF »
Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats.
X. Wang, Y.-x. Luo, Y.-y. He, F.-q. Li, H.-s. Shi, L.-f. Xue, Y.-x. Xue, and L. Lu (2010)
J. Neurosci. 30, 12632-12641
   Abstract »    Full Text »    PDF »
Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis.
M. J. Drummond, C. S. Fry, E. L. Glynn, H. C. Dreyer, S. Dhanani, K. L. Timmerman, E. Volpi, and B. B. Rasmussen (2009)
J. Physiol. 587, 1535-1546
   Abstract »    Full Text »    PDF »
The Switch I Region of Rheb Is Critical for Its Interaction with FKBP38.
D. Ma, X. Bai, S. Guo, and Y. Jiang (2008)
J. Biol. Chem. 283, 25963-25970
   Abstract »    Full Text »    PDF »

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