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Science 319 (5860): 163-164

Copyright © 2008 by the American Association for the Advancement of Science

A Few to Flip the Angiogenic Switch

Shahin Rafii and David Lyden

A relatively small number of endothelial progenitor cells have a profound effect on tumor growth and metastasis.

The authors are at Howard Hughes Medical Institute, Weill Cornell Medical College, New York, NY 10065, USA. E-mail: dcl2001{at}; srafii{at}

A target for antiangiogenic therapy: Vascular endothelium derived from glioblastoma.
A. Hormigo, B.-S. Ding, and S. Rafii (2011)
PNAS 108, 4271-4272
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Suppression of Tumor Angiogenesis by G{alpha}13 Haploinsufficiency.
L. Chen, J. J. Zhang, S. Rafii, and X.-Y. Huang (2009)
J. Biol. Chem. 284, 27409-27415
   Abstract »    Full Text »    PDF »
High Levels of Circulating VEGFR2+ Bone Marrow-Derived Progenitor Cells Correlate with Metastatic Disease in Patients with Pediatric Solid Malignancies.
M. Taylor, J. Rossler, B. Geoerger, A. Laplanche, O. Hartmann, G. Vassal, and F. Farace (2009)
Clin. Cancer Res. 15, 4561-4571
   Abstract »    Full Text »    PDF »
CEACAM1+ myeloid cells control angiogenesis in inflammation.
A. K. Horst, T. Bickert, N. Brewig, P. Ludewig, N. van Rooijen, U. Schumacher, N. Beauchemin, W. D. Ito, B. Fleischer, C. Wagener, et al. (2009)
Blood 113, 6726-6736
   Abstract »    Full Text »    PDF »
Stem Cells and the Natural History of Lung Cancer: Implications for Lung Cancer Screening.
R. J. van Klaveren, S. C. van't Westeinde, B.-J. de Hoop, and H. C. Hoogsteden (2009)
Clin. Cancer Res. 15, 2215-2218
   Abstract »    Full Text »    PDF »
Validation of a Standardized Method for Enumerating Circulating Endothelial Cells and Progenitors: Flow Cytometry and Molecular and Ultrastructural Analyses.
P. Mancuso, P. Antoniotti, J. Quarna, A. Calleri, C. Rabascio, C. Tacchetti, P. Braidotti, H.-K. Wu, A. J. Zurita, L. Saronni, et al. (2009)
Clin. Cancer Res. 15, 267-273
   Abstract »    Full Text »    PDF »
Enhanced Antitumor Efficacy of Clinical-Grade Vasculature-Targeted Liposomal Doxorubicin.
F. Pastorino, D. Di Paolo, F. Piccardi, B. Nico, D. Ribatti, A. Daga, G. Baio, C. E. Neumaier, C. Brignole, M. Loi, et al. (2008)
Clin. Cancer Res. 14, 7320-7329
   Abstract »    Full Text »    PDF »
Assessing Identity, Phenotype, and Fate of Endothelial Progenitor Cells.
K. K. Hirschi, D. A. Ingram, and M. C. Yoder (2008)
Arterioscler Thromb Vasc Biol 28, 1584-1595
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Migratory neighbors and distant invaders: tumor-associated niche cells.
J. Wels, R. N. Kaplan, S. Rafii, and D. Lyden (2008)
Genes & Dev. 22, 559-574
   Abstract »    Full Text »    PDF »

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