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Science 319 (5863): 576-577

Copyright © 2008 by the American Association for the Advancement of Science

The Toll of Cathepsin K Deficiency

Arthur M. Krieg and Grayson B. Lipford

An enzyme that is important to bone metabolism also acts in immune cell responses to pathogen DNA.

The authors are with the Coley Pharmaceutical Group, 93 Worcester Street, Wellesley, MA 02481, USA. E-mail: akrieg{at}

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882