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Science 319 (5863): 578-579

Copyright © 2008 by the American Association for the Advancement of Science

The Art of Assembly

Francis Szoka

Advances in delivering small interfering RNAs to specific tissues may bring these nucleotides closer to reality as therapeutic agents.

The author is in the Department of Biopharmaceutical Sciences and Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446, USA. E-mail: szoka{at}

The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides.
X. Ming, K. Carver, M. Fisher, R. Noel, J.-C. Cintrat, D. Gillet, J. Barbier, C. Cao, J. Bauman, and R. L. Juliano (2013)
Nucleic Acids Res. 41, 3673-3687
   Abstract »    Full Text »    PDF »
Targeting Melanoma Growth and Metastasis with Systemic Delivery of Liposome-Incorporated Protease-Activated Receptor-1 Small Interfering RNA.
G. J. Villares, M. Zigler, H. Wang, V. O. Melnikova, H. Wu, R. Friedman, M. C. Leslie, P. E. Vivas-Mejia, G. Lopez-Berestein, A. K. Sood, et al. (2008)
Cancer Res. 68, 9078-9086
   Abstract »    Full Text »    PDF »
Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides.
R. Juliano, Md. R. Alam, V. Dixit, and H. Kang (2008)
Nucleic Acids Res. 36, 4158-4171
   Abstract »    Full Text »    PDF »

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