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Science 319 (5868): 1348-1349

Copyright © 2008 by the American Association for the Advancement of Science

Sweet Conundrum

Morris J. Birnbaum

High blood glucose concentration causes a transcription factor to be modified with a sugar moiety, triggering the liver to produce yet more glucose.

Institute of Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA. E-mail: birnbaum{at}

A PGC-1{alpha}-O-GlcNAc Transferase Complex Regulates FoxO Transcription Factor Activity in Response to Glucose.
M. P. Housley, N. D. Udeshi, J. T. Rodgers, J. Shabanowitz, P. Puigserver, D. F. Hunt, and G. W. Hart (2009)
J. Biol. Chem. 284, 5148-5157
   Abstract »    Full Text »    PDF »
O-GlcNAc Regulates FoxO Activation in Response to Glucose.
M. P. Housley, J. T. Rodgers, N. D. Udeshi, T. J. Kelly, J. Shabanowitz, D. F. Hunt, P. Puigserver, and G. W. Hart (2008)
J. Biol. Chem. 283, 16283-16292
   Abstract »    Full Text »    PDF »

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