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Science 320 (5876): 619-620

Copyright © 2008 by the American Association for the Advancement of Science

How Frustration Leads to Inflammation

Luke A. J. O'Neill

A molecular basis for asbestos-induced inflammation may lie in a particular component of the inflammasome protein complex.

School of Biochemistry and Immunology, Trinity College, Dublin, Ireland. E-mail: laoneill{at}

NLRP3 deletion protects from hyperoxia-induced acute lung injury.
J. Fukumoto, I. Fukumoto, P. T. Parthasarathy, R. Cox, B. Huynh, G. K. Ramanathan, R. B. Venugopal, D. S. Allen-Gipson, R. F. Lockey, and N. Kolliputi (2013)
Am J Physiol Cell Physiol 305, C182-C189
   Abstract »    Full Text »    PDF »
Effect of Size Fractionation on the Toxicity of Amosite and Libby Amphibole Asbestos.
K. E. Duncan, A. J. Ghio, L. A. Dailey, A. M. Bern, E. A. Gibbs-Flournoy, D. J. Padilla-Carlin, V. L. Roggli, and R. B. Devlin (2010)
Toxicol. Sci. 118, 420-434
   Abstract »    Full Text »    PDF »

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