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Science 320 (5879): 1019-1020

Copyright © 2008 by the American Association for the Advancement of Science

SNO Removal

Arne Holmgren

Reduced thioredoxin denitrosylates caspase-3, a key protein involved in cell death.

Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden. E-mail: arne.holmgren{at}

High glucose sensitizes adult cardiomyocytes to ischaemia/reperfusion injury through nitrative thioredoxin inactivation.
R. Luan, S. Liu, T. Yin, W. B. Lau, Q. Wang, W. Guo, H. Wang, and L. Tao (2009)
Cardiovasc Res 83, 294-302
   Abstract »    Full Text »    PDF »
Regulation of the Catalytic Activity and Structure of Human Thioredoxin 1 via Oxidation and S-Nitrosylation of Cysteine Residues.
S. I. Hashemy and A. Holmgren (2008)
J. Biol. Chem. 283, 21890-21898
   Abstract »    Full Text »    PDF »

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