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Science 321 (5897): 1785-1787

Copyright © 2008 by the American Association for the Advancement of Science

The Metastasis Cascade

Christoph A. Klein

The view of evolution of tumor cells toward metastasis takes a new twist.

Division of Oncogenomics, Department of Pathology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany. E-mail: christoph.klein{at}

c-Myc expression and MEK1-induced Erk2 nuclear localization are required for TGF-beta induced epithelial-mesenchymal transition and invasion in prostate cancer.
M. D. Amatangelo, S. Goodyear, D. Varma, and M. E. Stearns (2012)
Carcinogenesis 33, 1965-1975
   Abstract »    Full Text »    PDF »
Molecular mechanism of pancreatic tumor metastasis inhibition by Gd@C82(OH)22 and its implication for de novo design of nanomedicine.
S.-g. Kang, G. Zhou, P. Yang, Y. Liu, B. Sun, T. Huynh, H. Meng, L. Zhao, G. Xing, C. Chen, et al. (2012)
PNAS 109, 15431-15436
   Abstract »    Full Text »    PDF »
DEDD Interacts with PI3KC3 to Activate Autophagy and Attenuate Epithelial-Mesenchymal Transition in Human Breast Cancer.
Q. Lv, W. Wang, J. Xue, F. Hua, R. Mu, H. Lin, J. Yan, X. Lv, X. Chen, and Z.-W. Hu (2012)
Cancer Res. 72, 3238-3250
   Abstract »    Full Text »    PDF »
Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1.
I. Ota, X.-Y. Li, Y. Hu, and S. J. Weiss (2009)
PNAS 106, 20318-20323
   Abstract »    Full Text »    PDF »
Functional Significance of Secreted Frizzled-Related Protein 1 in Metastatic Renal Cell Carcinomas.
S. Saini, J. Liu, S. Yamamura, S. Majid, K. Kawakami, H. Hirata, and R. Dahiya (2009)
Cancer Res. 69, 6815-6822
   Abstract »    Full Text »    PDF »
Super competition as a possible mechanism to pioneer precancerous fields.
C. Rhiner and E. Moreno (2009)
Carcinogenesis 30, 723-728
   Abstract »    Full Text »    PDF »

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