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Science 322 (5907): 1483-1484

Copyright © 2008 by the American Association for the Advancement of Science

Fat Stress and Liver Resistance

Wataru Ogawa1 and Masato Kasuga1,2

Communication among immune and fat cells in adipose tissue and liver hepatocytes underlies the pathogenesis of obesity-related insulin resistance.

1Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.

2Research Institute, International Medical Center of Japan, Tokyo 162-8655, Japan. E-mail: kasuga{at}

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T. Sartorius, S. Z. Lutz, M. Hoene, J. Waak, A. Peter, C. Weigert, H.-G. Rammensee, P. J. Kahle, H.-U. Haring, and A. M. Hennige (2012)
FASEB J 26, 1799-1809
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AMP-activated protein kinase {alpha}2 is an essential signal in the regulation of insulin-stimulated fatty acid uptake in control-fed and high-fat-fed mice.
M. J. Abbott, S. Constantinescu, and L. P. Turcotte (2012)
Exp Physiol 97, 603-617
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Fetuin-A Regulation of Calcified Matrix Metabolism.
W. Jahnen-Dechent, A. Heiss, C. Schafer, and M. Ketteler (2011)
Circ. Res. 108, 1494-1509
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