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Science 323 (5914): 588-589

Copyright © 2009 by the American Association for the Advancement of Science

The Force Is with Us

Martin A. Schwartz

Through changes in protein conformation and interactions, cells sense and respond to forces at their point of attachment to extracellular matrix.

Departments of Microbiology, Cell Biology, and Biomedical Engineering, Cardiovascular Research Center and Mellon Urological Cancer Research Institute, University of Virginia, Charlottesville, VA 22908, USA. E-mail: maschwartz{at}

Mechanosensing through focal adhesion-anchored intermediate filaments.
M. Gregor, S. Osmanagic-Myers, G. Burgstaller, M. Wolfram, I. Fischer, G. Walko, G. P. Resch, A. Jorgl, H. Herrmann, and G. Wiche (2014)
FASEB J 28, 715-729
   Abstract »    Full Text »    PDF »
Heart genetics in a small package, exploiting the condensed genome of Ciona intestinalis.
C. D. Cota, F. Segade, and B. Davidson (2014)
Briefings in Functional Genomics 13, 3-14
   Abstract »    Full Text »    PDF »
Atomic force microscopy - looking at mechanosensors on the cell surface.
J. J. Heinisch, P. N. Lipke, A. Beaussart, S. El Kirat Chatel, V. Dupres, D. Alsteens, and Y. F. Dufrene (2012)
J. Cell Sci. 125, 4189-4195
   Abstract »    Full Text »    PDF »
Protein Kinase G and Focal Adhesion Kinase Converge on Src/Akt/{beta}-Catenin Signaling Module in Osteoblast Mechanotransduction.
H. Rangaswami, R. Schwappacher, T. Tran, G. C. Chan, S. Zhuang, G. R. Boss, and R. B. Pilz (2012)
J. Biol. Chem. 287, 21509-21519
   Abstract »    Full Text »    PDF »
The Vinculin C-terminal Hairpin Mediates F-actin Bundle Formation, Focal Adhesion, and Cell Mechanical Properties.
K. Shen, C. E. Tolbert, C. Guilluy, V. S. Swaminathan, M. E. Berginski, K. Burridge, R. Superfine, and S. L. Campbell (2011)
J. Biol. Chem. 286, 45103-45115
   Abstract »    Full Text »    PDF »
Cardiac myocyte remodeling mediated by N-cadherin-dependent mechanosensing.
A. Chopra, E. Tabdanov, H. Patel, P. A. Janmey, and J. Y. Kresh (2011)
Am J Physiol Heart Circ Physiol 300, H1252-H1266
   Abstract »    Full Text »    PDF »
Cyclic GMP and Protein Kinase G Control a Src-Containing Mechanosome in Osteoblasts.
H. Rangaswami, R. Schwappacher, N. Marathe, S. Zhuang, D. E. Casteel, B. Haas, Y. Chen, A. Pfeifer, H. Kato, S. Shattil, et al. (2010)
Science Signaling 3, ra91
   Abstract »    Full Text »    PDF »
Vinculin Is Indispensable for Repopulation by Hematopoietic Stem Cells, Independent of Integrin Function.
T. Ohmori, Y. Kashiwakura, A. Ishiwata, S. Madoiwa, J. Mimuro, Y. Furukawa, and Y. Sakata (2010)
J. Biol. Chem. 285, 31763-31773
   Abstract »    Full Text »    PDF »
Tethering of Intercellular Adhesion Molecule on Target Cells Is Required for LFA-1-Dependent NK Cell Adhesion and Granule Polarization.
C. C. Gross, J. A. Brzostowski, D. Liu, and E. O. Long (2010)
J. Immunol. 185, 2918-2926
   Abstract »    Full Text »    PDF »

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