Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 323 (5921): 1567-1568

Copyright © 2009 by the American Association for the Advancement of Science

IMMUNOLOGY:
Two-in-One Designer Antibodies

Paul W. H. I. Parren1 and Dennis R. Burton2

An antibody is engineered to recognize two different proteins with high affinity, opening the door to improved combination therapies for cancers and infections.


1Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands. E-mail: p.parren{at}genmab.com

2Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. E-mail: burton{at}scripps.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Engineering of stable bispecific antibodies targeting IL-17A and IL-23.
R. Mabry, K. E. Lewis, M. Moore, P. A. McKernan, T. R. Bukowski, K. Bontadelli, T. Brender, S. Okada, K. Lum, J. West, et al. (2010)
Protein Eng. Des. Sel. 23, 115-127
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882