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Science 323 (5921): 1567-1568

Copyright © 2009 by the American Association for the Advancement of Science

Two-in-One Designer Antibodies

Paul W. H. I. Parren1 and Dennis R. Burton2

An antibody is engineered to recognize two different proteins with high affinity, opening the door to improved combination therapies for cancers and infections.

1Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands. E-mail: p.parren{at}

2Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. E-mail: burton{at}

Engineering of stable bispecific antibodies targeting IL-17A and IL-23.
R. Mabry, K. E. Lewis, M. Moore, P. A. McKernan, T. R. Bukowski, K. Bontadelli, T. Brender, S. Okada, K. Lum, J. West, et al. (2010)
Protein Eng. Des. Sel. 23, 115-127
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