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Science 324 (5924): 192-194

Copyright © 2009 by the American Association for the Advancement of Science

Puzzling Patterns of Predisposition

Patrick J. Pollard and Peter J. Ratcliffe

Mutations in a gene that encodes a metabolic enzyme have been linked to certain brain tumors, but is the gene a tumor suppressor or an oncogene?

Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford OX3 7BN, UK. E-mail: pjr{at}

Cells Lacking the Fumarase Tumor Suppressor Are Protected from Apoptosis through a Hypoxia-Inducible Factor-Independent, AMPK-Dependent Mechanism.
C. Bardella, M. Olivero, A. Lorenzato, M. Geuna, J. Adam, L. O'Flaherty, P. Rustin, I. Tomlinson, P. J. Pollard, and M. F. Di Renzo (2012)
Mol. Cell. Biol. 32, 3081-3094
   Abstract »    Full Text »    PDF »
Differential Activity of NADPH-Producing Dehydrogenases Renders Rodents Unsuitable Models to Study IDH1R132 Mutation Effects in Human Glioblastoma.
N. A. Atai, N. A. Renkema-Mills, J. Bosman, N. Schmidt, D. Rijkeboer, W. Tigchelaar, K. S. Bosch, D. Troost, A. Jonker, F. E. Bleeker, et al. (2011)
Journal of Histochemistry & Cytochemistry 59, 489-503
   Abstract »    Full Text »    PDF »
Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.
L. O'Flaherty, J. Adam, L. C. Heather, A. V. Zhdanov, Y.-L. Chung, M. X. Miranda, J. Croft, S. Olpin, K. Clarke, C. W. Pugh, et al. (2010)
Hum. Mol. Genet. 19, 3844-3851
   Abstract »    Full Text »    PDF »
JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation.
Y. Tanaka, K. Okamoto, K. Teye, T. Umata, N. Yamagiwa, Y. Suto, Y. Zhang, and M. Tsuneoka (2010)
EMBO J. 29, 1510-1522
   Abstract »    Full Text »    PDF »

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