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Science 324 (5925): 343-344

Copyright © 2009 by the American Association for the Advancement of Science

Ceramides--Friend or Foe in Hypoxia?

C. Michael Crowder

Molecular details of how nematode cells respond to a low-oxygen environment suggest a possible mechanism by which mammalian cells survive hypoxic conditions.

Departments of Anesthesiology and Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. E-mail: crowderm{at}

Dihydroceramide-based Response to Hypoxia.
C. M. Devlin, T. Lahm, W. C. Hubbard, M. Van Demark, K. C. Wang, X. Wu, A. Bielawska, L. M. Obeid, M. Ivan, and I. Petrache (2011)
J. Biol. Chem. 286, 38069-38078
   Abstract »    Full Text »    PDF »
Differential Molecular Responses of Rice and Wheat Coleoptiles to Anoxia Reveal Novel Metabolic Adaptations in Amino Acid Metabolism for Tissue Tolerance.
R. N. Shingaki-Wells, S. Huang, N. L. Taylor, A. J. Carroll, W. Zhou, and A. H. Millar (2011)
Plant Physiology 156, 1706-1724
   Abstract »    Full Text »    PDF »
Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-{gamma} coactivator-1{alpha} and -1{beta} in cultured myotubes.
D. O. Espinoza, L. G. Boros, S. Crunkhorn, H. Gami, and M. E. Patti (2010)
FASEB J 24, 1003-1014
   Abstract »    Full Text »    PDF »

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