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Science 324 (5929): 890-891

Copyright © 2009 by the American Association for the Advancement of Science


Ovulation Signals

Rajesha Duggavathi1, and Bruce D. Murphy2

Successful mammalian reproduction requires that the female gamete (oocyte or egg) acquires, within the growing ovarian follicle, the ability to be fertilized. Failure to initiate or complete follicle development, or defects in the oocyte (such as aneuploidy) result in infertility. On page 938 in this issue, Fan et al. (1) describe cellular signaling pathways in the mouse ovary that support follicle maturation and, ultimately, the discharge of a mature egg. The findings could help elucidate the underlying molecular nature of ovarian pathology and infertility-producing conditions in humans.

1 Animal Science, McGill University, Ste-Anne-de-Bellevue, Quebec, H9X 3V9 Canada.
2 Centre de recherche en reproduction animale, Université de Montréal, St-Hyacinthe, J2S 7C6 Canada.

E-mail: raj.duggavathi{at}; bruce.d.murphy{at}

Role of leptin receptors in granulosa cells during ovulation.
L. Dupuis, Y. Schuermann, T. Cohen, D. Siddappa, A. Kalaiselvanraja, M. Pansera, V. Bordignon, and R. Duggavathi (2014)
Reproduction 147, 221-229
   Abstract »    Full Text »    PDF »
Increased Expression of Kindlin 2 in Luteinized Granulosa Cells Correlates With Androgen Receptor Level in Patients with Polycystic Ovary Syndrome Having Hyperandrogenemia.
M. Yang, J. Du, D. Lu, C. Ren, H. Shen, J. Qiao, X. Chen, and H. Zhang (2013)
Reproductive Sciences
   Abstract »    Full Text »    PDF »
Ovarian antral folliculogenesis during the human menstrual cycle: a review.
A. R. Baerwald, G. P. Adams, and R. A. Pierson (2012)
Hum. Reprod. Update 18, 73-91
   Abstract »    Full Text »    PDF »
Dietary Supplementation with 0.8% L-Arginine between Days 0 and 25 of Gestation Reduces Litter Size in Gilts.
X. Li, F. W. Bazer, G. A. Johnson, R. C. Burghardt, D. W. Erikson, J. W. Frank, T. E. Spencer, I. Shinzato, and G. Wu (2010)
J. Nutr. 140, 1111-1116
   Abstract »    Full Text »    PDF »

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