Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 324 (5931): 1155-1156

Copyright © 2009 by the American Association for the Advancement of Science

Cell Biology

Sorting Out Diabetes

Charisse M. Orme, and Jonathan S. Bogan

Early during the development of type 2 diabetes, insulin's ability to stimulate the cellular uptake of glucose from the blood is compromised (1). Muscle is the main tissue responsible for this absorption, and insulin enhances glucose movement into muscle cells through the GLUT4 transporter at the cell surface (2, 3). This hallmark action of insulin is conserved in vertebrates, and the molecular machinery by which it occurs is thought to be similar among mammals. On page 1192 of this issue, Vassilopoulos et al. (4) identify a key protein that mediates insulin action in humans, but not in mice, a distinction with potential implications for understanding glucose metabolism and diabetes pathophysiology.

Section of Endocrinology and Metabolism, Department of Internal Medicine, and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520-8020, USA.

E-mail: jonathan.bogan{at}yale.edu



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882