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Science 324 (5934): 1527-1528

Copyright © 2009 by the American Association for the Advancement of Science


Bridging the Gap and Staying Local

Martin Korte

Long-term memory storage requires the transcription of specific genes in neurons (1). It also requires that the proteins encoded by these transcripts localize to regions in the neurons that forge the communicative neuronal connections, or synapses (2). Yet, how do gene products generated in the neuronal cell body (soma) "know" to which of all the neuron's synapses (up to 30,000) they have to be targeted? Two reports, by Wang et al. (3) on page 1536 of this issue and by Okada et al. (4), explore how long-lasting memory can be implemented at specific synapses.

Zoological Institute, Division of Cellular Neurobiology, TU Braunschweig, D-38106 Germany.

E-mail: m.korte{at}

Metaplasticity governs compartmentalization of synaptic tagging and capture through brain-derived neurotrophic factor (BDNF) and protein kinase M{zeta} (PKM{zeta}).
S. Sajikumar and M. Korte (2011)
PNAS 108, 2551-2556
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