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Science 325 (5941): 684-685

Copyright © 2009 by the American Association for the Advancement of Science

Cell Biology

Lethal Traffic Jam

Eefjan Breukink

The antibiotics chloramphenicol and tetracycline were discovered in the late 1940s shortly after the introduction of penicillin (1). Elucidation of the structure of the ribosome (2, 3) revealed how they bind to this target structure and inhibit protein synthesis. On page 753 in this issue, van Stelten et al. (4) demonstrate another mode of action for these antibiotics, involving the destruction of a complex that allows proteins to be translocated across (or into) the bacterial membrane (5).

Department of Chemical Biology and Organic Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands.

E-mail: e.j.breukink{at}uu.nl

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