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Science 325 (5946): 1353-1354

Copyright © 2009 by the American Association for the Advancement of Science


Went Fishing, Caught a Snake

Dies Meijer

A highly ordered, insulating layer of lipids and proteins known as the myelin sheath surrounds neuronal axons in our nervous system, allowing the rapid conduction of electrical impulses along nerve fibers. Myelin is laid down and maintained by dedicated neuroglia cells—oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system. Formation of the myelin sheath is under strict axonal control and involves the wrapping of vast amounts of glial membrane around axons (1). The process is initiated by axon-glial cell contact, which elicits an adenosine 3',5'-monophosphate (cAMP) signal within the glial cell. This signal drives myelin formation (2), but the molecular nature of the communication that triggers it has not been clear. On page 1402 of this issue, Monk et al. (3) provide compelling evidence for a cell surface receptor in Schwann cells that induces cAMP and myelin production in response to the targeted axon.

Department of Cell Biology and Genetics, ErasmusMC, 3000 CA Rotterdam, Netherlands.

E-mail: d.meijer{at}

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