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Science 325 (5948): 1635-1636

Copyright © 2009 by the American Association for the Advancement of Science

Cell Biology

Evolving Cell Signals

Mark O. Collins

Protein phosphorylation has emerged as a ubiquitous regulatory switch in cell signaling networks. Improved methods to purify and characterize phosphopeptides have led to an explosion of phosphorylation site data, and we can now explore how protein phosphorylation evolved. This question has been tackled by two studies in this issue. On page 1686, Tan et al. (1) report that tyrosine residues (which can be phosphorylated) have been selectively lost through metazoan evolution. On page 1682, Holt et al. (2) show that most phosphorylation sites shift position in rapidly evolving, disordered regions of proteins.

Proteomic Mass Spectrometry Group, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

E-mail: moc{at}

ERK-Mediated Phosphorylation of Fibroblast Growth Factor Receptor 1 on Ser777 Inhibits Signaling.
M. Zakrzewska, E. M. Haugsten, B. Nadratowska-Wesolowska, A. Oppelt, B. Hausott, Y. Jin, J. Otlewski, J. Wesche, and A. Wiedlocha (2013)
Science Signaling 6, ra11
   Abstract »    Full Text »    PDF »
Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity.
R. Hodeify, A. Tarcsafalvi, J. Megyesi, R. L. Safirstein, and P. M. Price (2011)
Am J Physiol Renal Physiol 300, F1171-F1179
   Abstract »    Full Text »    PDF »
Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis.
J. L. Jewell, E. Oh, L. Ramalingam, M. A. Kalwat, V. S. Tagliabracci, L. Tackett, J. S. Elmendorf, and D. C. Thurmond (2011)
J. Cell Biol. 193, 185-199
   Abstract »    Full Text »    PDF »
NHE3 Activity Is Dependent on Direct Phosphoinositide Binding at the N Terminus of Its Intracellular Cytosolic Region.
S. Mohan, C. M. Tse, S. B. Gabelli, R. Sarker, B. Cha, K. Fahie, M. Nadella, N. C. Zachos, B. Tu-Sekine, D. Raben, et al. (2010)
J. Biol. Chem. 285, 34566-34578
   Abstract »    Full Text »    PDF »
Evolution of Characterized Phosphorylation Sites in Budding Yeast.
A. N. Nguyen Ba and A. M. Moses (2010)
Mol. Biol. Evol. 27, 2027-2037
   Abstract »    Full Text »    PDF »

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