Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 327 (5965): 528-529

Copyright © 2010 by the American Association for the Advancement of Science


Arsonists in Rheumatoid Arthritis

Guy A. Zimmerman, and Andrew S. Weyrich

Platelets are small anucleate cells that circulate in the blood of mammals and are critical effectors of hemostasis, blood clotting, and wound repair. Rheumatoid arthritis is a chronic inflammatory disease of humans that involves the innate and adaptive limbs of the host immune system, and is thought to be autoimmune in nature. Traditionally, platelets and rheumatoid arthritis don't go together. On page 580 of this issue, Boilard et al. (1) report that they do—microparticles released by platelets may be incendiary devices in the conflagration of a hot, swollen, and painful rheumatoid joint.

Department of Medicine, University of Utah, Salt Lake City, UT 84112, USA.

E-mail: guy.zimmerman{at}

Platelets as Cellular Effectors of Inflammation in Vascular Diseases.
M. T. Rondina, A. S. Weyrich, and G. A. Zimmerman (2013)
Circ. Res. 112, 1506-1519
   Abstract »    Full Text »    PDF »
Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators.
J. Dalli and C. N. Serhan (2012)
Blood 120, e60-e72
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882