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Emmanuel D. Levy,1
Christian R. Landry,2
Stephen W. Michnick1
Living cells are complex systems that are constantly making decisions in response to internal or external signals. Among the most notable carriers of information are protein kinases and phosphatases, enzymes that receive inputs from cell surface or internal receptors and determine what actions should be taken in response, by phosphorylating or dephosphorylating substrates. How are these enzymes organized in the cell to capture and relay information in coordinated responses to signals? On page 1043 of this issue, Breitkreutz et al. (1) provide a key clue to this puzzle, describing how protein kinases and phosphatases in budding yeast are associated with other proteins and, most notably, with each other.
1 Département de Biochimie, Université de Montréal, Montréal, Quebec, Canada H3T 1J4. 2 Université Laval, Département de Biologie, PROTEO and Institute for Integrative and Systems Biology, Québec, Québec, Canada.
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In Science Magazine
Ashton Breitkreutz, Hyungwon Choi, Jeffrey R. Sharom, Lorrie Boucher, Victor Neduva, Brett Larsen, Zhen-Yuan Lin, Bobby-Joe Breitkreutz, Chris Stark, Guomin Liu, Jessica Ahn, Danielle Dewar-Darch, Teresa Reguly, Xiaojing Tang, Ricardo Almeida, Zhaohui Steve Qin, Tony Pawson, Anne-Claude Gingras, Alexey I. Nesvizhskii, and Mike Tyers (21 May 2010) Science328 (5981), 1043.
[DOI: 10.1126/science.1176495] |Abstract »|Full Text »|PDF »|Supporting Online Material »