Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 328 (5981): 983-984

Copyright © 2010 by the American Association for the Advancement of Science

Cell Signaling

Signaling Through Cooperation

Emmanuel D. Levy,1 Christian R. Landry,2 Stephen W. Michnick1

Living cells are complex systems that are constantly making decisions in response to internal or external signals. Among the most notable carriers of information are protein kinases and phosphatases, enzymes that receive inputs from cell surface or internal receptors and determine what actions should be taken in response, by phosphorylating or dephosphorylating substrates. How are these enzymes organized in the cell to capture and relay information in coordinated responses to signals? On page 1043 of this issue, Breitkreutz et al. (1) provide a key clue to this puzzle, describing how protein kinases and phosphatases in budding yeast are associated with other proteins and, most notably, with each other.

1 Département de Biochimie, Université de Montréal, Montréal, Quebec, Canada H3T 1J4.
2 Université Laval, Département de Biologie, PROTEO and Institute for Integrative and Systems Biology, Québec, Québec, Canada.

E-mail: stephen.michnick{at}umontreal.ca


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Synthetic Oleanane Triterpenoids: Multifunctional Drugs with a Broad Range of Applications for Prevention and Treatment of Chronic Disease.
K. T. Liby and M. B. Sporn (2012)
Pharmacol. Rev. 64, 972-1003
   Abstract »    Full Text »    PDF »
Protein abundance is key to distinguish promiscuous from functional phosphorylation based on evolutionary information.
E. D. Levy, S. W. Michnick, and C. R. Landry (2012)
Phil Trans R Soc B 367, 2594-2606
   Abstract »    Full Text »    PDF »
Large-scale phosphoproteomic analysis of membrane proteins in renal proximal and distal tubule.
M. Feric, B. Zhao, J. D. Hoffert, T. Pisitkun, and M. A. Knepper (2011)
Am J Physiol Cell Physiol 300, C755-C770
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882