Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 328 (5982): 1113-1114

Copyright © 2010 by the American Association for the Advancement of Science


Beige Can Be Slimming

Jeff Ishibashi, and Patrick Seale

How can we decrease the body's energy efficiency? The answer to this could be used to fight the exploding obesity crisis. Our ability to accumulate and retain energy reserves once provided a survival advantage. However, these ingrained energy-conservation pathways are now driving unprecedented weight gain in modern societies where calorie-dense food pervades. Burning off excess fuel (analogous to heating a house in winter with the windows open) may be an effective therapeutic avenue to reduce obesity when diet and exercise are not enough. On page 1158 in this issue, Vegiopoulos et al. demonstrate that the fatty acid derivatives called prostaglandins encourage adipocytes (fat cells) to do exactly this—waste energy through increased heat production (1).

Institute for Diabetes, Obesity and Metabolism and the Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

E-mail: sealep{at}

Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice.
M. Rosell, M. Kaforou, A. Frontini, A. Okolo, Y.-W. Chan, E. Nikolopoulou, S. Millership, M. E. Fenech, D. MacIntyre, J. O. Turner, et al. (2014)
Am J Physiol Endocrinol Metab 306, E945-E964
   Abstract »    Full Text »    PDF »
Oleoylethanolamide enhances {beta}-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat.
J. Suarez, P. Rivera, S. Arrabal, A. Crespillo, A. Serrano, E. Baixeras, F. J. Pavon, M. Cifuentes, R. Nogueiras, J. Ballesteros, et al. (2014)
Dis. Model. Mech. 7, 129-141
   Abstract »    Full Text »    PDF »
Growth Differentiation Factor-5 Promotes Brown Adipogenesis in Systemic Energy Expenditure.
E. Hinoi, Y. Nakamura, S. Takada, H. Fujita, T. Iezaki, S. Hashizume, S. Takahashi, Y. Odaka, T. Watanabe, and Y. Yoneda (2014)
Diabetes 63, 162-175
   Abstract »    Full Text »    PDF »
Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease.
J. L. McManaman, E. S. Bales, D. J. Orlicky, M. Jackman, P. S. MacLean, S. Cain, A. E. Crunk, A. Mansur, C. E. Graham, T. A. Bowman, et al. (2013)
J. Lipid Res. 54, 1346-1359
   Abstract »    Full Text »    PDF »
Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice.
W. Shen, C.-C. Chuang, K. Martinez, T. Reid, J. M. Brown, L. Xi, L. Hixson, R. Hopkins, J. Starnes, and M. McIntosh (2013)
J. Lipid Res. 54, 909-922
   Abstract »    Full Text »    PDF »
The adipose organ at a glance.
S. Cinti (2012)
Dis. Model. Mech. 5, 588-594
   Abstract »    Full Text »    PDF »
Genome-Wide Profiling of Peroxisome Proliferator-Activated Receptor {gamma} in Primary Epididymal, Inguinal, and Brown Adipocytes Reveals Depot-Selective Binding Correlated with Gene Expression.
M. S. Siersbaek, A. Loft, M. M. Aagaard, R. Nielsen, S. F. Schmidt, N. Petrovic, J. Nedergaard, and S. Mandrup (2012)
Mol. Cell. Biol. 32, 3452-3463
   Abstract »    Full Text »    PDF »
Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity.
J. Auffret, S. Viengchareun, N. Carre, R. G. P. Denis, C. Magnan, P.-Y. Marie, A. Muscat, B. Feve, M. Lombes, and N. Binart (2012)
FASEB J 26, 3728-3737
   Abstract »    Full Text »    PDF »
K. Sarjeant and J. M. Stephens (2012)
Cold Spring Harb Perspect Biol 4, a008417
   Abstract »    Full Text »    PDF »
Short-term sympathoadrenal inhibition augments the thermogenic response to {beta}-adrenergic receptor stimulation.
S. A. Newsom, J. C. Richards, T. K. Johnson, J. N. Kuzma, M. C. Lonac, R. J. Paxton, G. M. Rynn, W. F. Voyles, and C. Bell (2010)
J. Endocrinol. 206, 307-315
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882