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Science 328 (5985): 1495-1496

Copyright © 2010 by the American Association for the Advancement of Science


HDL miR-ed Down by SREBP Introns

Michael S. Brown, Jin Ye, Joseph L. Goldstein

Animal cells must maintain a membrane cholesterol-to-phospholipid ratio within tight limits for normal function. Elaborate mechanisms control the cellular input of cholesterol from endogenous synthesis or uptake from plasma lipoproteins. Much less is known about the factors that regulate the output of cholesterol from cells. On pages 1566 and 1570 of this issue, Najafi-Shoushtari et al. (1) and Rayner et al. (2) show that cholesterol output is controlled by the same genes that regulate cholesterol input, but in a reciprocal manner and through an unexpected mechanism.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

E-mail: mike.brown{at}; joe.goldstein{at}

MicroRNA Control of High-Density Lipoprotein Metabolism and Function.
K. J. Rayner and K. J. Moore (2014)
Circ. Res. 114, 183-192
   Abstract »    Full Text »    PDF »
Anti-atherosclerosis or No Anti-atherosclerosis: That is the miR-33 question.
A. M. Naar (2013)
Arterioscler Thromb Vasc Biol 33, 447-448
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Early steps in steroidogenesis: intracellular cholesterol trafficking: Thematic Review Series: Genetics of Human Lipid Diseases.
W. L. Miller and H. S. Bose (2011)
J. Lipid Res. 52, 2111-2135
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miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling.
A. Davalos, L. Goedeke, P. Smibert, C. M. Ramirez, N. P. Warrier, U. Andreo, D. Cirera-Salinas, K. Rayner, U. Suresh, J. C. Pastor-Pareja, et al. (2011)
PNAS 108, 9232-9237
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Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity.
R. D. Cox and C. D. Church (2011)
Dis. Model. Mech. 4, 155-164
   Abstract »    Full Text »    PDF »
MicroRNAs in Metabolism and Metabolic Diseases.
V. Rottiers, S. H. Najafi-Shoushtari, F. Kristo, S. Gurumurthy, L. Zhong, Y. Li, D. E. Cohen, R. E. Gerszten, N. Bardeesy, R. Mostoslavsky, et al. (2011)
Cold Spring Harb Symp Quant Biol 76, 225-233
   Abstract »    Full Text »    PDF »

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