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Science 328 (5985): 1495-1496

Copyright © 2010 by the American Association for the Advancement of Science

Medicine

HDL miR-ed Down by SREBP Introns

Michael S. Brown, Jin Ye, Joseph L. Goldstein

Animal cells must maintain a membrane cholesterol-to-phospholipid ratio within tight limits for normal function. Elaborate mechanisms control the cellular input of cholesterol from endogenous synthesis or uptake from plasma lipoproteins. Much less is known about the factors that regulate the output of cholesterol from cells. On pages 1566 and 1570 of this issue, Najafi-Shoushtari et al. (1) and Rayner et al. (2) show that cholesterol output is controlled by the same genes that regulate cholesterol input, but in a reciprocal manner and through an unexpected mechanism.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

E-mail: mike.brown{at}utsouthwestern.edu; joe.goldstein{at}utsouthwestern.edu

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