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Science 328 (5986): 1641-1642

Copyright © 2010 by the American Association for the Advancement of Science


Tackling Two Diseases with HDL

Göran K. Hansson, and Magnus Björkholm

High-density lipoproteins (HDLs) transport cholesterol from peripheral tissues to the liver, helping to protect against diseases such as atherosclerosis. On page 1689 in this issue, Yvan-Charvet et al. present an entirely new role for HDL in regulating stem cell proliferation in the bone marrow (1). A relationship between cellular cholesterol content, HDL, and cells of the myelomonocytic lineage opens up the possibility that disorders characterized by the proliferation of immature white blood cells could be treated by targeting cholesterol transport in these cells.

Center for Molecular Medicine and Department of Medicine, Karolinska Institutet, SE-17176 Stockholm, Sweden.

E-mail: goran.hansson{at}

HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.
E. L. Gautier, M. Westerterp, N. Bhagwat, S. Cremers, A. Shih, O. Abdel-Wahab, D. Lutjohann, G. J. Randolph, R. L. Levine, A. R. Tall, et al. (2013)
J. Exp. Med. 210, 339-353
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