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Science 329 (5990): 397-398

Copyright © 2010 by the American Association for the Advancement of Science


Wnt Fans the Flames in Obesity

Da Young Oh, and Jerrold M. Olefsky

Obesity is linked to major adverse health outcomes such as insulin resistance and type 2 diabetes (1). The mechanisms underlying insulin resistance in this state are multiple and complex, including the recruitment of immune cells, particularly macrophages, to adipose tissue. This results in chronic, low grade inflammation that is causally associated with insulin resistance. With obesity, adipose tissue mass expands and adipocyte (fat cell) size increases. Collectively, adipocytes constitute the body's largest endocrine organ, producing an array of peptide hormones called adipokines (2). On page 454 of this issue, Ouchi et al. (3) report that a protein secreted by adipocytes acts as an anti-inflammatory adipokine, restraining the chronic inflammatory state and consequently improving insulin sensitivity.

Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA.

E-mail: jolefsky{at}

Wnt5a promotes human colon cancer cell migration and invasion but does not augment intestinal tumorigenesis in Apc1638N mice.
E. R. M. Bakker, A. M. Das, W. Helvensteijn, P. F. Franken, S. Swagemakers, M. A. van der Valk, T. L. M. ten Hagen, E. J. Kuipers, W. van Veelen, and R. Smits (2013)
Carcinogenesis 34, 2629-2638
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A heterogeneous lineage origin underlies the phenotypic and molecular differences of white and beige adipocytes.
W. Liu, T. Shan, X. Yang, S. Liang, P. Zhang, Y. Liu, X. Liu, and S. Kuang (2013)
J. Cell Sci. 126, 3527-3532
   Abstract »    Full Text »    PDF »

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