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Science 329 (5993): 766-767

Copyright © 2010 by the American Association for the Advancement of Science

Cell Biology

The Proteome in Balance

Darren Hutt1, and William E. Balch1,2

Inherited mutations and polymorphisms that alter the sequence of a polypeptide can affect its folding and stability, triggering disease at birth and during aging. A central cellular mechanism for generating and maintaining normal protein folds is the protein homeostasis or proteostasis network (referred to as the PN) (1). These processes sustain functional proteins as well as direct their removal from the cell during protein turnover or in response to misfolding. This "yin-yang" balance is critical for normal cellular, tissue, and organismal physiology. On page 805 in this issue, Okiyoneda et al. (2) show that the PN operates globally, constantly surveying protein folds, from co-translational insertion of proteins into the endoplasmic reticulum (ER) to removal of unstable proteins at the plasma membrane.

1 Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
2 Department of Chemical Physiology, Skaggs Institute for Chemical Biology, and Institute for Childhood and Neglected Diseases, Scripps Research Institute, La Jolla, CA 92037, USA.

E-mail: webalch{at}scripps.edu

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Histone Deacetylase Inhibitor (HDACi) Suberoylanilide Hydroxamic Acid (SAHA)-mediated Correction of {alpha}1-Antitrypsin Deficiency.
M. Bouchecareilh, D. M. Hutt, P. Szajner, T. R. Flotte, and W. E. Balch (2012)
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FK506 Binding Protein 8 Peptidylprolyl Isomerase Activity Manages a Late Stage of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Folding and Stability.
D. M. Hutt, D. M. Roth, M. A. Chalfant, R. T. Youker, J. Matteson, J. L. Brodsky, and W. E. Balch (2012)
J. Biol. Chem. 287, 21914-21925
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Prolactin and Growth Hormone Aggregates in Secretory Granules: The Need to Understand the Structure of the Aggregate.
P. S. Dannies (2012)
Endocr. Rev. 33, 254-270
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Comparison of Plasma Membrane Proteomic Changes of Arabidopsis Suspension-Cultured Cells (T87 Line) after Cold and ABA Treatment in Association with Freezing Tolerance Development.
B. Li, D. Takahashi, Y. Kawamura, and M. Uemura (2012)
Plant Cell Physiol. 53, 543-554
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Protein Folding and Quality Control in the ER.
K. Araki and K. Nagata (2011)
Cold Spring Harb Perspect Biol 3, a007526
   Abstract »    Full Text »    PDF »
Emergent Properties of Proteostasis in Managing Cystic Fibrosis.
W. E. Balch, D. M. Roth, and D. M. Hutt (2011)
Cold Spring Harb Perspect Biol 3, a004499
   Abstract »    Full Text »    PDF »
Proteostasis Strategies for Restoring {alpha}1-Antitrypsin Deficiency.
M. Bouchecareilh, J. J. Conkright, and W. E. Balch (2010)
7, 415-422
   Abstract »    Full Text »    PDF »

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