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Science 329 (5993): 767-769

Copyright © 2010 by the American Association for the Advancement of Science

Immunology

β-Catenin Balances Immunity

Ira Mellman1, and Björn E. Clausen2

The human immune system ensures protective responses against pathogen-associated antigens while ignoring the individual's own proteins, carbohydrates, nucleic acids, and lipids. This balance of tolerance to "self " against immunity to "non-self " is crucial because its failure can lead to autoimmune and inflammatory disorders when tolerance is insufficient, or to unresolved chronic infections and possibly cancer when tolerance is too robust. On page 849 in this issue, Manicassamy et al. (1) demonstrate that β-catenin signaling, well known for its role in development, is key to balancing tolerance and immunity through the control of dendritic cell (DC) function.

1 Genentech, Inc., South San Francisco, CA 94080, USA.
2 Department of Immunology, Erasmus MC, University Medical Center, 3015 GE Rotterdam, Netherlands.

E-mail: mellman.ira{at}gene.com; b.clausen{at}erasmusmc.nl


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Pathogen-specific TLR2 Protein Activation Programs Macrophages to Induce Wnt-{beta}-Catenin Signaling.
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