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Science 329 (5996): 1158-1159

Copyright © 2010 by the American Association for the Advancement of Science


Targeting the Core of Transcription

D. Grahame Hardie

A adenosine 5'-monophosphate–activated protein kinase (AMPK) is a cellular energy sensor expressed across eukaryotes (1). It is switched on by stresses that disturb energy balance and triggers both acute responses and longer-term adaptations by affecting gene expression. It was thought that its transcriptional effects were mediated largely via phosphorylation of transcription factors (2) or coregulators (3, 4) that recruit RNA polymerase II to gene promoters. However, on page 1201 of this issue, Bungard et al. (5) suggest that AMPK might cause additional effects by phosphorylating a chromatin protein, histone H2B.

College of Life Science, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.

E-mail: d.g.hardie{at}

AMP-Activated Protein Kinase Regulates E3 Ligases in Rodent Heart.
K. K. Baskin and H. Taegtmeyer (2011)
Circ. Res. 109, 1153-1161
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