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Science 330 (6009): 1330-1331

Copyright © 2010 by the American Association for the Advancement of Science

Cell Biology

Opening the Cellular Poison Cabinet

Seamus J. Martin

In complex multicellular organisms, millions of cells die each day as a result of stress, injury, or infection, and as part of the natural cell turnover process that is essential to optimal tissue functioning. Remarkably, cell death in most of these situations is orchestrated by the dying cell itself, a form of cellular suicide called apoptosis (1). On page 1390 in this issue, Ren et al. (2) help to resolve how cells execute this process.

Molecular Cell Biology Laboratory, Department of Genetics, Trinity College, Dublin 2, Ireland.

E-mail: martinsj{at}

Cytoplasmic localization of DGK{zeta} exerts a protective effect against p53-mediated cytotoxicity.
T. Tanaka, M. Okada, Y. Hozumi, K. Tachibana, C. Kitanaka, Y. Hamamoto, A. M. Martelli, M. K. Topham, M. Iino, and K. Goto (2013)
J. Cell Sci. 126, 2785-2797
   Abstract »    Full Text »    PDF »
Quality Control of Mitochondrial Proteostasis.
M. J. Baker, T. Tatsuta, and T. Langer (2011)
Cold Spring Harb Perspect Biol 3, a007559
   Abstract »    Full Text »    PDF »

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