Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 334 (6061): 1354-1355

Copyright © 2011 by the American Association for the Advancement of Science

Beleaguered Immunity

John M. McDowell

Plants defend themselves against pathogens with an immune system that detects foreign molecules and endogenous danger signals (1). Pathogens interfere with this response by secreting effector proteins that target nodes in the underlying cell signaling network (2). In turn, plants guard these nodes with surveillance proteins that detect effectors' sabotage attempts and trigger antimicrobial responses, including programmed cell death at the infection site. Because this "effector-triggered immunity" underpins breeding for disease resistance in crops, there is much interest in understanding how surveillance proteins are activated and how this alarm signal triggers immune responses. One well-studied immune regulatory protein is called ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) because mutations in the EDS1 gene compromise immunity (3), but its molecular function has not been clear. Two papers in this issue, by Bhattacharjee et al. (4) on page 1405 and Heidrich et al. (5) on page 1401, identify proteins that interact with EDS1 and describe the spatial mobility of these protein complexes. These studies also show that EDS1 is attacked by pathogen effector proteins, prompting a reappraisal of its role in regulating the immune response.

Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA 24061-0323, USA.

E-mail: johnmcd{at}

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882