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Science 334 (6062): 1501-1502

Copyright © 2011 by the American Association for the Advancement of Science

Autophagy in Tumor Immunity

Ravi K. Amaravadi

Autophagy can promote the survival of tumor cells through nutrients recovered from degrading and recycling damaged organelles. How this mechanism can stimulate or limit the immune system's attack on tumor cells has not been well understood (1). On page 1573 of this issue, Michaud et al. (2) show that in mice, chemotherapy-induced autophagy causes the release of adenosine 5'-triphosphate (ATP) from tumor cells, thereby stimulating antitumor immune responses.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.

E-mail: ravi.amaravadi{at}

Hyperactivation of Mammalian Target of Rapamycin Complex 1 (mTORC1) Promotes Breast Cancer Progression through Enhancing Glucose Starvation-induced Autophagy and Akt Signaling.
Y. Chen, H. Wei, F. Liu, and J.-L. Guan (2014)
J. Biol. Chem. 289, 1164-1173
   Abstract »    Full Text »    PDF »
Autophagy Induced by Conventional Chemotherapy Mediates Tumor Cell Sensitivity to Immunotherapy.
R. Ramakrishnan, C. Huang, H.-I. Cho, M. Lloyd, J. Johnson, X. Ren, S. Altiok, D. Sullivan, J. Weber, E. Celis, et al. (2012)
Cancer Res. 72, 5483-5493
   Abstract »    Full Text »    PDF »

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