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Science 336 (6083): 813-814

Copyright © 2012 by the American Association for the Advancement of Science

Ancient Sensor for Ancient Drug

Reuben J. Shaw1, and Lewis C. Cantley2

Salicylate, a compound found in willow tree bark, is the active breakdown product of aspirin, and has been used for medicinal purposes since ancient times. However, the molecular mechanism underlying the beneficial effects of salicylate has been unclear. On page 918 of this issue, Hawley et al. (1) show that salicylate activates the cellular metabolic regulator adenosine monophosphate (AMP)–activated protein kinase (AMPK), which stimulates fat utilization in mice.

1 Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
2 Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

E-mail: shaw{at}; lewis_cantley{at}

The Med1 Subunit of the Mediator Complex Induces Liver Cell Proliferation and Is Phosphorylated by AMP Kinase.
N. Viswakarma, Y. Jia, L. Bai, Q. Gao, B. Lin, X. Zhang, P. Misra, A. Rana, S. Jain, F. J. Gonzalez, et al. (2013)
J. Biol. Chem. 288, 27898-27911
   Abstract »    Full Text »    PDF »
Prevention and Intervention Trials for Colorectal Cancer.
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Targeting the IKK{beta}/mTOR/VEGF Signaling Pathway as a Potential Therapeutic Strategy for Obesity-Related Breast Cancer.
C.-T. Chen, Y. Du, H. Yamaguchi, J.-M. Hsu, H.-P. Kuo, G. N. Hortobagyi, and M.-C. Hung (2012)
Mol. Cancer Ther. 11, 2212-2221
   Abstract »    Full Text »    PDF »

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882