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Science 336 (6085): 1120-1121

Copyright © 2012 by the American Association for the Advancement of Science

When Less Signaling Is More

Oliver M. Bannard, and Jason G. Cyster

A crowded party means lots of sensory inputs and the need to "tune out" distracting signals to have productive interactions. On page 1178 in this issue, Khalil et al. (1) suggest that in a crowded environment, B cells too must tune out distracting inputs so that they can be responsive to key interactions.

Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California–San Francisco, CA 94143–0414, USA.

E-mail: jason.cyster{at}

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882