Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 337 (6093): 418-419

Copyright © 2012 by the American Association for the Advancement of Science

dSarm-ing Axon Degeneration

Xiaomeng Milton Yu, and Liqun Luo

Plucked from the tree, a leaf withers. Such a loss of vitality upon removal from the whole appears so natural that one may take it for granted as a passive and unstoppable process. But is it? Although cell death was long thought to be a passive process, we now know that at least one form of cell death, apoptosis (from Greek "falling away"), is an active process that can be blocked by inhibiting a specific signaling pathway (1). On page 481 of this issue, Osterloh et al. (2) find that the death of a portion of a nerve cell, the axon, after it is severed from the cell body, can be dramatically slowed by the inactivation of just one gene. The discovery has important implications for understanding the molecular mechanisms of axon degeneration, as well as for developing drugs against neurodegenerative diseases.

Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA.

E-mail: lluo{at}

A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis.
I. Fogh, A. Ratti, C. Gellera, K. Lin, C. Tiloca, V. Moskvina, L. Corrado, G. Soraru, C. Cereda, S. Corti, et al. (2014)
Hum. Mol. Genet. 23, 2220-2231
   Abstract »    Full Text »    PDF »
Resveratrol Inhibits the TRIF-Dependent Pathway by Upregulating Sterile Alpha and Armadillo Motif Protein, Contributing to Anti-Inflammatory Effects after Respiratory Syncytial Virus Infection.
T. Liu, N. Zang, N. Zhou, W. Li, X. Xie, Y. Deng, L. Ren, X. Long, S. Li, L. Zhou, et al. (2014)
J. Virol. 88, 4229-4236
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882