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Science 338 (6108): 748-749

Copyright © 2012 by the American Association for the Advancement of Science

A Decorated Virus Cannot Hide

Roland W. Herzog1, and David A. Ostrov2

The coagulation system protects our bodies from excessive loss of blood from a leaky or damaged vessel, whereas the immune system protects us from invading pathogens such as viruses. Unexpected links between these two systems suggest their coevolution (1, 2). On page 795 in this issue, Doronin et al. show that an essential protein for the clotting process binds to a virus that has entered the blood stream, thereby allowing the immune system to sense the invader and mount a rapid and potent antiviral response (3).

1 Department of Pediatrics University of Florida, Gainesville, FL 32610, USA.
2 Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.

E-mail: rherzog{at}; ostroda{at}

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