Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 339 (6116): 148-150

Copyright © 2013 by the American Association for the Advancement of Science

When Metabolism and Epigenetics Converge

Paolo Sassone-Corsi

Various cell types respond differently to the environment by using distinct circuits of genomic reprogramming. How does a fixed DNA blueprint allow flexibility in managing changes to environmental signals? Environmental inputs such as nutrition can modulate cell metabolism, and critical links between metabolism and epigenetic control—now widely thought to include chromatin remodeling, histone modifications, DNA methylation, and microRNA pathways (1)—are beginning to emerge (2, 3). Two reports in this issue, by Shimazu et al. (4) on page 211 and Shyh-Chang et al. (5) on page 222, provide insights into this connection.

Center for Epigenetics and Metabolism, Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.

E-mail: psc{at}

Unique Metabolic Features of Stem Cells, Cardiomyocytes, and Their Progenitors.
J. A. Gaspar, M. X. Doss, J. G. Hengstler, C. Cadenas, J. Hescheler, and A. Sachinidis (2014)
Circ. Res. 114, 1346-1360
   Abstract »    Full Text »    PDF »
Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation.
A. Burton, C. Azevedo, C. Andreassi, A. Riccio, and A. Saiardi (2013)
PNAS 110, 18970-18975
   Abstract »    Full Text »    PDF »
Yeast Phospholipase C Is Required for Normal Acetyl-CoA Homeostasis and Global Histone Acetylation.
L. Galdieri, J. Chang, S. Mehrotra, and A. Vancura (2013)
J. Biol. Chem. 288, 27986-27998
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882