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Science 339 (6117): 279-280

Copyright © 2013 by the American Association for the Advancement of Science

Hormones and the Social Brain

Bruce S. McEwen

Glucocorticoids are steroid hormones that function in immune responses, metabolism, development, and a range of behaviors. On pages 332 and 335 in this issue, Barik et al. (1) and Niwa et al. (2), respectively, challenge our understanding of the sites and mechanisms of action of glucocorticoid "stress hormones" in the mammalian brain, revealing surprising neuroanatomical specificity and pointing to the participation of other regulatory factors and cellular interactions, as well as the importance of gene-environment interactions in the effects of glucocorticoids.

Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10065 USA.

mcewen{at}rockefeller.edu

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