Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. Signal., 11 November 2008
Vol. 1, Issue 45, p. ra12
[DOI: 10.1126/scisignal.2000037]
RESEARCH
Editor's Summary
Finding the Right Candidate
A genome-wide RNAi screen in human colon cancer cells, followed by two additional validation steps, reveals new components of the Wnt pathway. Combining RNAi analysis with protein-protein interaction data provides a powerful approach that not only identifies new players in a signaling pathway, but also provides functional insight about the modulators, leading to the generation of testable hypotheses.
Citation: M. B. Major, B. S. Roberts, J. D. Berndt, S. Marine, J. Anastas, N. Chung, M. Ferrer, X. Yi, C. L. Stoick-Cooper, P. D. von Haller, L. Kategaya, A. Chien, S. Angers, M. MacCoss, M. A. Cleary, W. T. Arthur, R. T. Moon, New Regulators of Wnt/β-Catenin Signaling Revealed by Integrative Molecular Screening. Sci. Signal.1, ra12 (2008).
The editors suggest the following Related Resources on Science sites:
In Science Signaling
RESEARCH
Richard G. James, Travis L. Biechele, William H. Conrad, Nathan D. Camp, Daniel M. Fass, Michael B. Major, Karen Sommer, XianHua Yi, Brian S. Roberts, Michele A. Cleary, William T. Arthur, Michael MacCoss, David J. Rawlings, Stephen J. Haggarty, and Randall T. Moon (26 May 2009) Sci. Signal.2 (72), ra25.
[DOI: 10.1126/scisignal.2000230] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
PRESENTATIONS
Jason D. Berndt, Travis L. Biechele, Randall T. Moon, and Michael B. Major (12 May 2009) Sci. Signal.2 (70), pt4.
[DOI: 10.1126/scisignal.270pt4] |Abstract »|Full Text »|PDF »|Slideshow »
EDITORS' CHOICE
Wei Wong (25 November 2008) Sci. Signal.1 (47), ec401.
[DOI: 10.1126/scisignal.147ec401] |Abstract »
PODCASTS
Michael B. Major, Randall T. Moon, and Annalisa M. VanHook (11 November 2008) Sci. Signal.1 (45), pc11.
[DOI: 10.1126/scisignal.145pc11] |Abstract »|Full Text »|Podcast »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transcription-Based Reporters of Wnt/{beta}-Catenin Signaling.
T. L. Biechele, A. M. Adams, and R. T. Moon (2009)
CSH Protocols
2009, pdb.prot5223
|Abstract »|Full Text »
Bruton's Tyrosine Kinase Revealed as a Negative Regulator of Wnt-{beta}-Catenin Signaling.
R. G. James, T. L. Biechele, W. H. Conrad, N. D. Camp, D. M. Fass, M. B. Major, K. Sommer, X. Yi, B. S. Roberts, M. A. Cleary, et al. (2009)
Science Signaling
2, ra25
|Abstract »|Full Text »|PDF »
Integrative Analysis of Genome-Wide RNA Interference Screens.
J. D. Berndt, T. L. Biechele, R. T. Moon, and M. B. Major (2009)
Science Signaling
2, pt4
|Abstract »|Full Text »|PDF »
