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Sci. Signal., 23 September 2008
Vol. 1, Issue 38, p. ra5
[DOI: 10.1126/scisignal.1160940]

RESEARCH

Editor's Summary

A Growth-Promoting Ubiquitin Ligase
Genetic knockout of the ubiquitin ligase Nedd4 decreases insulin-like growth factor 1 (IGF-1) and insulin signaling and causes delayed embryonic development, reduced growth and body weight, and neonatal lethality. Elevated Grb10 in the Nedd4-deficient cells appears to cause mislocalization of the IGF-1 receptor and prevent receptor signaling at the plasma membrane. Thus, by regulating the abundance of Grb10, a negative regulator of IGF-1 and insulin signaling, Nedd4 positively influences growth.

Citation: X. R. Cao, N. L. Lill, N. Boase, P. P. Shi, D. R. Croucher, H. Shan, J. Qu, E. M. Sweezer, T. Place, P. A. Kirby, R. J. Daly, S. Kumar, B. Yang, Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling. Sci. Signal. 1, ra5 (2008).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
PKC-{theta} Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation.
T. Gruber, N. Hermann-Kleiter, R. Hinterleitner, F. Fresser, R. Schneider, G. Gastl, J. M. Penninger, and G. Baier (2009)
Science Signaling 2, ra30
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Anterograde Transport of Surfactant Protein C Proprotein to Distal Processing Compartments Requires PPDY-mediated Association with Nedd4 Ubiquitin Ligases.
A. Kotorashvili, S. J. Russo, S. Mulugeta, S. Guttentag, and M. F. Beers (2009)
J. Biol. Chem. 284, 16667-16678
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