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Sci. Signal., 9 September 2008
Vol. 1, Issue 36, p. ra3
[DOI: 10.1126/scisignal.1161577]

RESEARCH

Editor's Summary

Unveiling p110β
Phosphatidylinositide 3-kinase (PI3K) signaling has been implicated in the response to insulin and various growth factors. However, the specific role of the β isoform of the PI3K catalytic subunit (p110β) has been unclear. Analysis of mouse mutants carrying a catalytically inactive form of p110β reveals that it possesses noncatalytic as well as catalytic functions. Moreover, its catalytic activity is involved in sustaining the response to insulin signaling and in mediating forms of breast cancer associated with oncogenic epidermal growth factor signaling.

Citation: E. Ciraolo, M. Iezzi, R. Marone, S. Marengo, C. Curcio, C. Costa, O. Azzolino, C. Gonella, C. Rubinetto, H. Wu, W. Dastrù, E. L. Martin, L. Silengo, F. Altruda, E. Turco, L. Lanzetti, P. Musiani, T. Rückle, C. Rommel, J. M. Backer, G. Forni, M. P. Wymann, E. Hirsch, Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development. Sci. Signal. 1, ra3 (2008).

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882