Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. Signal., 23 September 2008
Vol. 1, Issue 38, p. ra5
A Growth-Promoting Ubiquitin Ligase
Genetic knockout of the ubiquitin ligase Nedd4 decreases insulin-like growth factor 1 (IGF-1) and insulin signaling and causes delayed embryonic development, reduced growth and body weight, and neonatal lethality. Elevated Grb10 in the Nedd4-deficient cells appears to cause mislocalization of the IGF-1 receptor and prevent receptor signaling at the plasma membrane. Thus, by regulating the abundance of Grb10, a negative regulator of IGF-1 and insulin signaling, Nedd4 positively influences growth.
Citation: X. R. Cao, N. L. Lill, N. Boase, P. P. Shi, D. R. Croucher, H. Shan, J. Qu, E. M. Sweezer, T. Place, P. A. Kirby, R. J. Daly, S. Kumar, B. Yang, Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling. Sci. Signal.1, ra5 (2008).