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Sci. Signal., 23 September 2008
Vol. 1, Issue 38, p. ra5
[DOI: 10.1126/scisignal.1160940]


Editor's Summary

A Growth-Promoting Ubiquitin Ligase
Genetic knockout of the ubiquitin ligase Nedd4 decreases insulin-like growth factor 1 (IGF-1) and insulin signaling and causes delayed embryonic development, reduced growth and body weight, and neonatal lethality. Elevated Grb10 in the Nedd4-deficient cells appears to cause mislocalization of the IGF-1 receptor and prevent receptor signaling at the plasma membrane. Thus, by regulating the abundance of Grb10, a negative regulator of IGF-1 and insulin signaling, Nedd4 positively influences growth.

Citation: X. R. Cao, N. L. Lill, N. Boase, P. P. Shi, D. R. Croucher, H. Shan, J. Qu, E. M. Sweezer, T. Place, P. A. Kirby, R. J. Daly, S. Kumar, B. Yang, Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling. Sci. Signal. 1, ra5 (2008).

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Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays.
A. Persaud, P. Alberts, E. M. Amsen, X. Xiong, J. Wasmuth, Z. Saadon, C. Fladd, J. Parkinson, and D. Rotin (2014)
Mol Syst Biol 5, 333
   Abstract »    Full Text »    PDF »
Endocytosis of Receptor Tyrosine Kinases.
L. K. Goh and A. Sorkin (2013)
Cold Spring Harb Perspect Biol 5, a017459
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SUMOylation Regulates the Homologous to E6-AP Carboxyl Terminus (HECT) Ubiquitin Ligase Rsp5p.
T. V. Novoselova, R.-S. Rose, H. M. Marks, and J. A. Sullivan (2013)
J. Biol. Chem. 288, 10308-10317
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HECT Domain-containing E3 Ubiquitin Ligase NEDD4L Negatively Regulates Wnt Signaling by Targeting Dishevelled for Proteasomal Degradation.
Y. Ding, Y. Zhang, C. Xu, Q.-H. Tao, and Y.-G. Chen (2013)
J. Biol. Chem. 288, 8289-8298
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Ubiquitin-dependent Regulation of Phospho-AKT Dynamics by the Ubiquitin E3 Ligase, NEDD4-1, in the Insulin-like Growth Factor-1 Response.
C.-D. Fan, M. A. Lum, C. Xu, J. D. Black, and X. Wang (2013)
J. Biol. Chem. 288, 1674-1684
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Upregulation of the E3 ligase NEDD4-1 by Oxidative Stress Degrades IGF-1 Receptor Protein in Neurodegeneration.
Y.-D. Kwak, B. Wang, J. J. Li, R. Wang, Q. Deng, S. Diao, Y. Chen, R. Xu, E. Masliah, H. Xu, et al. (2012)
J. Neurosci. 32, 10971-10981
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E3 ubiquitin-protein ligases in rat kidney collecting duct: response to vasopressin stimulation and withdrawal.
Y.-J. Lee, J.-E. Lee, H.-J. Choi, J.-S. Lim, H. J. Jung, M.-C. Baek, J. Frokiaer, S. Nielsen, and T.-H. Kwon (2011)
Am J Physiol Renal Physiol 301, F883-F896
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Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function.
A. Persaud, P. Alberts, M. Hayes, S. Guettler, I. Clarke, F. Sicheri, P. Dirks, B. Ciruna, and D. Rotin (2011)
EMBO J. 30, 3259-3273
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The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling.
P. P. Hsu, S. A. Kang, J. Rameseder, Y. Zhang, K. A. Ottina, D. Lim, T. R. Peterson, Y. Choi, N. S. Gray, M. B. Yaffe, et al. (2011)
Science 332, 1317-1322
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Functional Interaction of Phosphatase and Tensin Homologue (PTEN) with the E3 Ligase NEDD4-1 during Neuronal Response to Zinc.
Y.-D. Kwak, B. Wang, W. Pan, H. Xu, X. Jiang, and F.-F. Liao (2010)
J. Biol. Chem. 285, 9847-9857
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The Ubiquitin Ligase Nedd4-1 Is Required for Heart Development and Is a Suppressor of Thrombospondin-1.
F. Fouladkou, C. Lu, C. Jiang, L. Zhou, Y. She, J. R. Walls, H. Kawabe, N. Brose, R. M. Henkelman, A. Huang, et al. (2010)
J. Biol. Chem. 285, 6770-6780
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PKC-{theta} Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation.
T. Gruber, N. Hermann-Kleiter, R. Hinterleitner, F. Fresser, R. Schneider, G. Gastl, J. M. Penninger, and G. Baier (2009)
Science Signaling 2, ra30
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Anterograde Transport of Surfactant Protein C Proprotein to Distal Processing Compartments Requires PPDY-mediated Association with Nedd4 Ubiquitin Ligases.
A. Kotorashvili, S. J. Russo, S. Mulugeta, S. Guttentag, and M. F. Beers (2009)
J. Biol. Chem. 284, 16667-16678
   Abstract »    Full Text »    PDF »

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