Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. Signal., 30 September 2008
Vol. 1, Issue 39, p. ra7
[DOI: 10.1126/scisignal.1162925]

RESEARCH

Editor's Summary

Modulating Hedgehog Signals
Signaling initiated by Hedgehog (Hh) ligands is critical to tissue patterning in both vertebrates and invertebrates; however, the specific downstream mechanisms are distinct. For instance, Fused, a kinase crucial to fly Hh signaling, does not appear to be essential to Hh signaling in mammals. Evangelista et al. screened a mouse kinome small interfering RNA library and used stringent criteria to validate candidates for genes encoding proteins that enhance Hh signaling. Two of these, Nek1 and Prkra, appeared to regulate Hh signaling indirectly by affecting primary cilia formation. The kinase Cdc2l1, however, interacted with the negative regulator of Hh signaling Suppressor of Fused, thereby relieving its inhibition of the Glioma-associated family of transcription factors, suggesting that Cdc2l1 plays a direct role in the Hh signal transduction cascade in vertebrates.

Citation: M. Evangelista, T. Y. Lim, J. Lee, L. Parker, A. Ashique, A. S. Peterson, W. Ye, D. P. Davis, F. J. de Sauvage, Kinome siRNA Screen Identifies Regulators of Ciliogenesis and Hedgehog Signal Transduction. Sci. Signal. 1, ra7 (2008).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Variations in Hedgehog signaling: divergence and perpetuation in Sufu regulation of Gli.
L. Ruel and P. P. Therond (2009)
Genes & Dev. 23, 1843-1848
   Abstract »    Full Text »    PDF »
Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway.
V. L. Patterson, C. Damrau, A. Paudyal, B. Reeve, D. T. Grimes, M. E. Stewart, D. J. Williams, P. Siggers, A. Greenfield, and J. N. Murdoch (2009)
Hum. Mol. Genet. 18, 1719-1739
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 07 April 2009.
B. D. Manning and A. M. VanHook (2009)
Science Signaling 2, pc7
   Abstract »    Full Text »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882