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Sci. Signal., 30 September 2008
Vol. 1, Issue 39, p. ra7
[DOI: 10.1126/scisignal.1162925]


Editor's Summary

Modulating Hedgehog Signals
Signaling initiated by Hedgehog (Hh) ligands is critical to tissue patterning in both vertebrates and invertebrates; however, the specific downstream mechanisms are distinct. For instance, Fused, a kinase crucial to fly Hh signaling, does not appear to be essential to Hh signaling in mammals. Evangelista et al. screened a mouse kinome small interfering RNA library and used stringent criteria to validate candidates for genes encoding proteins that enhance Hh signaling. Two of these, Nek1 and Prkra, appeared to regulate Hh signaling indirectly by affecting primary cilia formation. The kinase Cdc2l1, however, interacted with the negative regulator of Hh signaling Suppressor of Fused, thereby relieving its inhibition of the Glioma-associated family of transcription factors, suggesting that Cdc2l1 plays a direct role in the Hh signal transduction cascade in vertebrates.

Citation: M. Evangelista, T. Y. Lim, J. Lee, L. Parker, A. Ashique, A. S. Peterson, W. Ye, D. P. Davis, F. J. de Sauvage, Kinome siRNA Screen Identifies Regulators of Ciliogenesis and Hedgehog Signal Transduction. Sci. Signal. 1, ra7 (2008).

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