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Sci. Signal., 30 September 2008
Vol. 1, Issue 39, p. ra7
[DOI: 10.1126/scisignal.1162925]
RESEARCH ARTICLES
Editor's Summary
Modulating Hedgehog Signals
Signaling initiated by Hedgehog (Hh) ligands is critical to tissue patterning in both vertebrates and invertebrates; however, the specific downstream mechanisms are distinct. For instance, Fused, a kinase crucial to fly Hh signaling, does not appear to be essential to Hh signaling in mammals. Evangelista et al. screened a mouse kinome small interfering RNA library and used stringent criteria to validate candidates for genes encoding proteins that enhance Hh signaling. Two of these, Nek1 and Prkra, appeared to regulate Hh signaling indirectly by affecting primary cilia formation. The kinase Cdc2l1, however, interacted with the negative regulator of Hh signaling Suppressor of Fused, thereby relieving its inhibition of the Glioma-associated family of transcription factors, suggesting that Cdc2l1 plays a direct role in the Hh signal transduction cascade in vertebrates.
Citation: M. Evangelista, T. Y. Lim, J. Lee, L. Parker, A. Ashique, A. S. Peterson, W. Ye, D. P. Davis, F. J. de Sauvage, Kinome siRNA Screen Identifies Regulators of Ciliogenesis and Hedgehog Signal Transduction. Sci. Signal.1, ra7 (2008).
Wei Wong (16 November 2010) Sci. Signal.3 (148), ec347.
[DOI: 10.1126/scisignal.3148ec347] |Abstract »
EDITORS' CHOICE
Stella M. Hurtley (27 July 2010) Sci. Signal.3 (132), ec233.
[DOI: 10.1126/scisignal.3132ec233] |Abstract »
PERSPECTIVES
Ljiljana Milenkovic and Matthew P. Scott (13 April 2010) Sci. Signal.3 (117), pe14.
[DOI: 10.1126/scisignal.3117pe14] |Abstract »|Full Text »|PDF »
EDITORS' CHOICE
Annalisa M. VanHook (8 December 2009) Sci. Signal.2 (100), ec393.
[DOI: 10.1126/scisignal.2100ec393] |Abstract »
RESEARCH ARTICLES
Amir M. Ashique, Youngshik Choe, Mattias Karlen, Scott R. May, Khanhky Phamluong, Mark J. Solloway, Johan Ericson, and Andrew S. Peterson (3 November 2009) Sci. Signal.2 (95), ra70.
[DOI: 10.1126/scisignal.2000602] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
RESEARCH ARTICLES
Helen Oi-Lam Cheung, Xiaoyun Zhang, Ana Ribeiro, Rong Mo, Shigeru Makino, Vijitha Puviindran, Kelvin K. L. Law, James Briscoe, and Chi-chung Hui (23 June 2009) Sci. Signal.2 (76), ra29.
[DOI: 10.1126/scisignal.2000405] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
PODCASTS
Brendan D. Manning and Annalisa M. VanHook (7 April 2009) Sci. Signal.2 (65), pc7.
[DOI: 10.1126/scisignal.265pc7] |Abstract »|Full Text »|Podcast »
In Science Magazine
EDITORS' CHOICE: HIGHLIGHTS OF THE RECENT LITERATURE
L. Bryan Ray (24 October 2008) Science322 (5901), 507c.
[DOI: 10.1126/science.322.5901.507c] |Full Text »|PDF »
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