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Sci. Signal., 14 October 2008
Vol. 1, Issue 41, p. ra8
Regulating Purinergic Signals
Extracellular ATP binds to and activates P2X receptors, ligand-gated ion channels that mediate calcium influx and, consequently, various physiological and pathophysiological processes. Chaumont et al. found that the calcium-sensitive protein VILIP1 bound to P2X2 receptors under basal conditions, thereby modulating P2X2 receptor mobility and function. Both ATP application and calcium influx promoted P2X2 receptor interactions with VILIP1, which were also increased in response to stimulation of hippocampal neurons under conditions known to elicit ATP release and P2X2 receptor activation.
Citation: S. Chaumont, V. Compan, E. Toulme, E. Richler, G. D. Housley, F. Rassendren, B. S. Khakh, Regulation of P2X2 Receptors by the Neuronal Calcium Sensor VILIP1. Sci. Signal.1, ra8 (2008).
Activation and Regulation of Purinergic P2X Receptor Channels.
C. Coddou, Z. Yan, T. Obsil, J. P. Huidobro-Toro, and S. S. Stojilkovic (2011)
|Abstract »|Full Text »|PDF »
Lipid Raft Association and Cholesterol Sensitivity of P2X1-4 Receptors for ATP: CHIMERAS AND POINT MUTANTS IDENTIFY INTRACELLULAR AMINO-TERMINAL RESIDUES INVOLVED IN LIPID REGULATION OF P2X1 RECEPTORS.