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Sci. Signal., 11 November 2008
Vol. 1, Issue 45, p. ra12
[DOI: 10.1126/scisignal.2000037]

RESEARCH ARTICLES

Editor's Summary

Finding the Right Candidate
A genome-wide RNAi screen in human colon cancer cells, followed by two additional validation steps, reveals new components of the Wnt pathway. Combining RNAi analysis with protein-protein interaction data provides a powerful approach that not only identifies new players in a signaling pathway, but also provides functional insight about the modulators, leading to the generation of testable hypotheses.

Citation: M. B. Major, B. S. Roberts, J. D. Berndt, S. Marine, J. Anastas, N. Chung, M. Ferrer, X. Yi, C. L. Stoick-Cooper, P. D. von Haller, L. Kategaya, A. Chien, S. Angers, M. MacCoss, M. A. Cleary, W. T. Arthur, R. T. Moon, New Regulators of Wnt/β-Catenin Signaling Revealed by Integrative Molecular Screening. Sci. Signal. 1, ra12 (2008).

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