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Sci. Signal., 11 November 2008
Vol. 1, Issue 45, p. ra12
[DOI: 10.1126/scisignal.2000037]
RESEARCH ARTICLES
Editor's Summary
Finding the Right Candidate
A genome-wide RNAi screen in human colon cancer cells, followed by two additional validation steps, reveals new components of the Wnt pathway. Combining RNAi analysis with protein-protein interaction data provides a powerful approach that not only identifies new players in a signaling pathway, but also provides functional insight about the modulators, leading to the generation of testable hypotheses.
Citation: M. B. Major, B. S. Roberts, J. D. Berndt, S. Marine, J. Anastas, N. Chung, M. Ferrer, X. Yi, C. L. Stoick-Cooper, P. D. von Haller, L. Kategaya, A. Chien, S. Angers, M. MacCoss, M. A. Cleary, W. T. Arthur, R. T. Moon, New Regulators of Wnt/β-Catenin Signaling Revealed by Integrative Molecular Screening. Sci. Signal.1, ra12 (2008).
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MEETING REPORTS
Folkert Verkaar, Ken M. Cadigan, and Renée van Amerongen (11 December 2012) Sci. Signal.5 (254), mr2.
[DOI: 10.1126/scisignal.2003714] |Abstract »|Full Text »|PDF »
EDITORIAL GUIDES
Nancy R. Gough and Michael B. Yaffe (15 February 2011) Sci. Signal.4 (160), eg2.
[DOI: 10.1126/scisignal.2001871] |Abstract »|Full Text »|PDF »
EDITORS' CHOICE
Wei Wong (28 September 2010) Sci. Signal.3 (141), ec294.
[DOI: 10.1126/scisignal.3141ec294] |Abstract »
EDITORS' CHOICE
Annalisa M. VanHook (31 August 2010) Sci. Signal.3 (137), ec262.
[DOI: 10.1126/scisignal.3137ec262] |Abstract »
RESEARCH ARTICLES
Richard G. James, Travis L. Biechele, William H. Conrad, Nathan D. Camp, Daniel M. Fass, Michael B. Major, Karen Sommer, XianHua Yi, Brian S. Roberts, Michele A. Cleary, William T. Arthur, Michael MacCoss, David J. Rawlings, Stephen J. Haggarty, and Randall T. Moon (26 May 2009) Sci. Signal.2 (72), ra25.
[DOI: 10.1126/scisignal.2000230] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
PRESENTATIONS
Jason D. Berndt, Travis L. Biechele, Randall T. Moon, and Michael B. Major (12 May 2009) Sci. Signal.2 (70), pt4.
[DOI: 10.1126/scisignal.270pt4] |Abstract »|Full Text »|PDF »|Slideshow »
EDITORS' CHOICE
Wei Wong (25 November 2008) Sci. Signal.1 (47), ec401.
[DOI: 10.1126/scisignal.147ec401] |Abstract »
PODCASTS
Michael B. Major, Randall T. Moon, and Annalisa M. VanHook (11 November 2008) Sci. Signal.1 (45), pc11.
[DOI: 10.1126/scisignal.145pc11] |Abstract »|Full Text »|Podcast »
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