Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 11 November 2008
Vol. 1, Issue 45, p. ra13
[DOI: 10.1126/scisignal.1165027]

RESEARCH ARTICLES

Editor's Summary

The Right Sort of Signal
Signaling by the transforming growth factor–β (TGF-β) family member Nodal is important in tissue patterning during embryonic development, among other processes. Nodal activates the transcription factors Smad 2 and 3 by binding to its receptor activin receptor–like kinase 4 (ALK4) and its co-receptor Cripto, a glycosylphosphatidylinositol (GPI)–anchored protein. Cripto is known to be important in the proteolytic processing and endocytosis of Nodal in lipid rafts. Here, Blanchet et al. show that Cripto thereafter is also needed in early endosomes to activate ALK4 by attenuating the sorting of Nodal to intraendosomal vesicles.

Citation: M.-H. Blanchet, J. A. Le Good, V. Oorschot, S. Baflast, G. Minchiotti, J. Klumperman, D. B. Constam, Cripto Localizes Nodal at the Limiting Membrane of Early Endosomes. Sci. Signal. 1, ra13 (2008).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
TAG1 Regulates the Endocytic Trafficking and Signaling of the Semaphorin3A Receptor Complex.
P. Dang, E. Smythe, and A. J. W. Furley (2012)
J. Neurosci. 32, 10370-10382
   Abstract »    Full Text »    PDF »
Sortilin Associates with Transforming Growth Factor-{beta} Family Proteins to Enhance Lysosome-mediated Degradation.
S. Kwon and J. L. Christian (2011)
J. Biol. Chem. 286, 21876-21885
   Abstract »    Full Text »    PDF »
Nodal Morphogens.
A. F. Schier (2009)
Cold Spring Harb Perspect Biol 1, a003459
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882