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Sci. Signal., 11 November 2008
Vol. 1, Issue 45, p. ra13
[DOI: 10.1126/scisignal.1165027]


Editor's Summary

The Right Sort of Signal
Signaling by the transforming growth factor–β (TGF-β) family member Nodal is important in tissue patterning during embryonic development, among other processes. Nodal activates the transcription factors Smad 2 and 3 by binding to its receptor activin receptor–like kinase 4 (ALK4) and its co-receptor Cripto, a glycosylphosphatidylinositol (GPI)–anchored protein. Cripto is known to be important in the proteolytic processing and endocytosis of Nodal in lipid rafts. Here, Blanchet et al. show that Cripto thereafter is also needed in early endosomes to activate ALK4 by attenuating the sorting of Nodal to intraendosomal vesicles.

Citation: M.-H. Blanchet, J. A. Le Good, V. Oorschot, S. Baflast, G. Minchiotti, J. Klumperman, D. B. Constam, Cripto Localizes Nodal at the Limiting Membrane of Early Endosomes. Sci. Signal. 1, ra13 (2008).

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TAG1 Regulates the Endocytic Trafficking and Signaling of the Semaphorin3A Receptor Complex.
P. Dang, E. Smythe, and A. J. W. Furley (2012)
J. Neurosci. 32, 10370-10382
   Abstract »    Full Text »    PDF »
Sortilin Associates with Transforming Growth Factor-{beta} Family Proteins to Enhance Lysosome-mediated Degradation.
S. Kwon and J. L. Christian (2011)
J. Biol. Chem. 286, 21876-21885
   Abstract »    Full Text »    PDF »
Nodal Morphogens.
A. F. Schier (2009)
Cold Spring Harb Perspect Biol 1, a003459
   Abstract »    Full Text »    PDF »

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