Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 25 November 2008
Vol. 1, Issue 47, p. ra14
[DOI: 10.1126/scisignal.1161938]


Editor's Summary

A ROCK in Stressful Times
Exposure of cells to ultraviolet B (UVB) radiation results in damage to DNA and the generation of mutations that can give rise to unchecked cellular proliferation. Thus, it is critically important to the prevention of skin cancers that the response to UVB-induced damage is to trigger apoptosis in the affected cells. In UVB-exposed cells, activation of members of the mitogen-activated protein kinase (MAPK) family, such as c-Jun N-terminal kinase (JNK), mediates this apoptotic response, but how UVB radiation activates signaling pathways upstream of JNK is unclear. Ongusaha et al. now show that exposure of keratinocytes to UVB radiation activates Rho-associated kinase 1 (ROCK1), which phosphorylates and activates the scaffold protein JNK-interacting protein 3 (JIP-3), which in turn recruits and activates JNK. Mice deficient in ROCK1 failed to mount as efficient an apoptotic response to UVB irradiation as did their wild-type counterparts, suggesting that ROCK1 is a critical early player in the response to UVB irradiation.

Citation: P. P. Ongusaha, H. H. Qi, L. Raj, Y.-B. Kim, S. A. Aaronson, R. J. Davis, Y. Shi, J. K. Liao, S. W. Lee, Identification of ROCK1 as an Upstream Activator of the JIP-3 to JNK Signaling Axis in Response to UVB Damage. Sci. Signal. 1, ra14 (2008).

Read the Full Text

ETS-1-mediated Transcriptional Up-regulation of CD44 Is Required for Sphingosine-1-phosphate Receptor Subtype 3-stimulated Chemotaxis.
W. Zhang, J. Zhao, J.-F. Lee, A. Gartung, H. Jawadi, W. L. Lambiv, K. V. Honn, and M.-J. Lee (2013)
J. Biol. Chem. 288, 32126-32137
   Abstract »    Full Text »    PDF »
ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53.
S. Vemula, J. Shi, R. S. Mali, P. Ma, Y. Liu, P. Hanneman, K. R. Koehler, E. Hashino, L. Wei, and R. Kapur (2012)
Blood 120, 2868-2878
   Abstract »    Full Text »    PDF »
Arf6-GEF BRAG1 Regulates JNK-Mediated Synaptic Removal of GluA1-Containing AMPA Receptors: A New Mechanism for Nonsyndromic X-Linked Mental Disorder.
K. R. Myers, G. Wang, Y. Sheng, K. K. Conger, J. E. Casanova, and J. J. Zhu (2012)
J. Neurosci. 32, 11716-11726
   Abstract »    Full Text »    PDF »
Toxin-induced RhoA Activity Mediates CCL1-triggered Signal Transducers and Activators of Transcription Protein Signaling.
S. Reipschlager, K. Kubatzky, S. Taromi, M. Burger, J. Orth, K. Aktories, and G. Schmidt (2012)
J. Biol. Chem. 287, 11183-11194
   Abstract »    Full Text »    PDF »
Rho Kinase Proteins--Pleiotropic Modulators of Cell Survival and Apoptosis.
C. A. STREET and B. A. BRYAN (2011)
Anticancer Res 31, 3645-3657
   Abstract »    Full Text »    PDF »
DDR1 Receptor Tyrosine Kinase Promotes Prosurvival Pathway through Notch1 Activation.
H.-G. Kim, S.-Y. Hwang, S. A. Aaronson, A. Mandinova, and S. W. Lee (2011)
J. Biol. Chem. 286, 17672-17681
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 02 December 2008.
S. W. Lee, P. P. Ongusaha, and A. M. VanHook (2008)
Science Signaling 1, pc13
   Abstract »    Full Text »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882