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Sci. Signal., 9 December 2008
Vol. 1, Issue 49, p. ra16
[DOI: 10.1126/scisignal.1163630]

RESEARCH ARTICLES

Editor's Summary

Revealing Kidney Formation Through Metagenes
By collecting the more than 30,000 genes into 650 groups called metagenes, Tsigelny et al. uncover genes that may orchestrate the transitions between stages of kidney development. Organization of the metagenes into self-organizing maps revealed up to eight distinct stages of kidney development. Entropy calculations of the self-organizing maps allowed the metagene-defined stages to be correlated with morphometric parameters and with specific gene networks. Genes included those already known for their involvement in kidney development as well as ones previously not implicated in this process of organogenesis, thus yielding new insight.

Citation: I. F. Tsigelny, V. L. Kouznetsova, D. E. Sweeney, W. Wu, K. T. Bush, S. K. Nigam, Analysis of Metagene Portraits Reveals Distinct Transitions During Kidney Organogenesis. Sci. Signal. 1, ra16 (2008).

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The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects.
M. M. Shah, J. B. Tee, T. Meyer, C. Meyer-Schwesinger, Y. Choi, D. E. Sweeney, T. F. Gallegos, K. Johkura, E. Rosines, V. Kouznetsova, et al. (2009)
Am J Physiol Renal Physiol 297, F1330-F1341
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