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Sci. Signal., 22 December 2009
Vol. 2, Issue 102, p. ra84
[DOI: 10.1126/scisignal.2000576]


Editor's Summary

Setting a Speed Limit on EGFR Traffic
Receptor tyrosine kinases interact with ligands at the cell surface to trigger intracellular signaling cascades. In some cases, these receptors are internalized, a process that can either enable them to initiate signaling cascades from intracellular membranes or target them for lysosomal degradation. Lissanu Deribe et al. connect acetylation of the microtubule cytoskeleton to regulation of delivery of epidermal growth factor receptors (EGFRs) to lysosomes. HDAC6, a cytoplasmic lysine deacetylase, was identified as binding to the inactive EGFR, stimulating deacetylation of {alpha}-tubulin, and decreasing the rate of delivery of EGFR from the early endosome to late endosomes or lysosomes. Phosphorylation of HDAC6, which decreased its activity, by activated EGFR created a negative feedback loop, leading to increased degradation of activated EGFRs.

Citation: Y. Lissanu Deribe, P. Wild, A. Chandrashaker, J. Curak, M. H. H. Schmidt, Y. Kalaidzidis, N. Milutinovic, I. Kratchmarova, L. Buerkle, M. J. Fetchko, P. Schmidt, S. Kittanakom, K. R. Brown, I. Jurisica, B. Blagoev, M. Zerial, I. Stagljar, I. Dikic, Regulation of Epidermal Growth Factor Receptor Trafficking by Lysine Deacetylase HDAC6. Sci. Signal. 2, ra84 (2009).

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The multiple-specificity landscape of modular peptide recognition domains.
D. Gfeller, F. Butty, M. Wierzbicka, E. Verschueren, P. Vanhee, H. Huang, A. Ernst, N. Dar, I. Stagljar, L. Serrano, et al. (2014)
Mol Syst Biol 7, 484
   Abstract »    Full Text »    PDF »
The LC3 interactome at a glance.
P. Wild, D. G. McEwan, and I. Dikic (2014)
J. Cell Sci. 127, 3-9
   Abstract »    Full Text »    PDF »
Extracellular Signal-regulated Kinase (ERK) Phosphorylates Histone Deacetylase 6 (HDAC6) at Serine 1035 to Stimulate Cell Migration.
K. A. Williams, M. Zhang, S. Xiang, C. Hu, J.-Y. Wu, S. Zhang, M. Ryan, A. D. Cox, C. J. Der, B. Fang, et al. (2013)
J. Biol. Chem. 288, 33156-33170
   Abstract »    Full Text »    PDF »
A Poor Prognosis Subtype of HNSCC Is Consistently Observed across Methylome, Transcriptome, and miRNome Analysis.
A. C. Jung, S. Job, S. Ledrappier, C. Macabre, J. Abecassis, A. de Reynies, and B. Wasylyk (2013)
Clin. Cancer Res. 19, 4174-4184
   Abstract »    Full Text »    PDF »
Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease.
N. Govindarajan, P. Rao, S. Burkhardt, F. Sananbenesi, O. M. Schluter, F. Bradke, J. Lu, and A. Fischer (2013)
EMBO Mol Med. 5, 52-63
   Abstract »    Full Text »    PDF »
DIAPH3 governs the cellular transition to the amoeboid tumour phenotype.
M. H. Hager, S. Morley, D. R. Bielenberg, S. Gao, M. Morello, I. N. Holcomb, W. Liu, G. Mouneimne, F. Demichelis, J. Kim, et al. (2012)
EMBO Mol Med. 4, 743-760
   Abstract »    Full Text »    PDF »
On Mammary Gland Growth Factors: Roles in Normal Development and in Cancer.
M.-C. Hung (2012)
Cold Spring Harb Perspect Biol 4, a013532
   Full Text »    PDF »
Histone Deacetylase 6 Associates With Ribosomes and Regulates De Novo Protein Translation During Arsenite Stress.
K. V. Kappeler, J. Zhang, T. N. Dinh, J. G. Strom, and Q. M. Chen (2012)
Toxicol. Sci. 127, 246-255
   Abstract »    Full Text »    PDF »
A novel GRK2/HDAC6 interaction modulates cell spreading and motility.
V. Lafarga, I. Aymerich, O. Tapia, F. Mayor Jr, and P. Penela (2012)
EMBO J. 31, 856-869
   Abstract »    Full Text »    PDF »
AIP and its interacting partners.
G. Trivellin and M. Korbonits (2011)
J. Endocrinol. 210, 137-155
   Abstract »    Full Text »    PDF »
Protein kinase CK2 regulates the formation and clearance of aggresomes in response to stress.
M. Watabe and T. Nakaki (2011)
J. Cell Sci. 124, 1519-1532
   Abstract »    Full Text »    PDF »
Spatial organization of transmembrane receptor signalling.
I. Bethani, S. S. Skanland, I. Dikic, and A. Acker-Palmer (2010)
EMBO J. 29, 2677-2688
   Abstract »    Full Text »    PDF »

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