Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 27 January 2009
Vol. 2, Issue 55, p. ra1
[DOI: 10.1126/scisignal.2000140]

RESEARCH ARTICLES

Editor's Summary

Micromanaging Development
By combining microarray gene expression data with occupancy by a key DNA binding transducer in the Notch pathway, Krejcí et al. set a gold standard for target genes that are regulated directly by Notch. The analysis also reveals incoherent network logic in which Notch signaling activates both positive and negative regulators of several pathways, which may allow Notch to micromanage multiple signaling networks and poise cells for different responses depending on the context. Detailed analysis of several Notch direct target genes in vivo reveals that many of the identified genes participate in regulation of adult muscle progenitors in Drosophila.

Citation: A. Krejcí, F. Bernard, B. E. Housden, S. Collins, S. J. Bray, Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic. Sci. Signal. 2, ra1 (2009).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dynamic CRM occupancy reflects a temporal map of developmental progression.
B. Wilczynski and E. E. M. Furlong (2014)
Mol Syst Biol 6, 383
   Abstract »    Full Text »    PDF »
Context-Dependent Enhancer Selection Confers Alternate Modes of Notch Regulation on argos.
B. E. Housden, A. Terriente-Felix, and S. J. Bray (2014)
Mol. Cell. Biol. 34, 664-672
   Abstract »    Full Text »    PDF »
Machine learning classification of cell-specific cardiac enhancers uncovers developmental subnetworks regulating progenitor cell division and cell fate specification.
S. M. Ahmad, B. W. Busser, D. Huang, E. J. Cozart, S. Michaud, X. Zhu, N. Jeffries, A. Aboukhalil, M. L. Bulyk, I. Ovcharenko, et al. (2014)
Development 141, 878-888
   Abstract »    Full Text »    PDF »
A Serrate-Notch-Canoe complex mediates essential interactions between glia and neuroepithelial cells during Drosophila optic lobe development.
R. Perez-Gomez, J. Slovakova, N. Rives-Quinto, A. Krejci, and A. Carmena (2013)
J. Cell Sci. 126, 4873-4884
   Abstract »    Full Text »    PDF »
Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling.
M. Kitade, V. M. Factor, J. B. Andersen, A. Tomokuni, K. Kaji, H. Akita, A. Holczbauer, D. Seo, J. U. Marquardt, E. A. Conner, et al. (2013)
Genes & Dev. 27, 1706-1717
   Abstract »    Full Text »    PDF »
Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme.
A. Terriente-Felix, J. Li, S. Collins, A. Mulligan, I. Reekie, F. Bernard, A. Krejci, and S. Bray (2013)
Development 140, 926-937
   Abstract »    Full Text »    PDF »
Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling.
J. Guiu, R. Shimizu, T. D'Altri, S. T. Fraser, J. Hatakeyama, E. H. Bresnick, R. Kageyama, E. Dzierzak, M. Yamamoto, L. Espinosa, et al. (2013)
J. Exp. Med. 210, 71-84
   Abstract »    Full Text »    PDF »
Dissecting the mechanisms of Notch induced hyperplasia.
A. Djiane, A. Krejci, F. Bernard, S. Fexova, K. Millen, and S. J. Bray (2013)
EMBO J. 32, 60-71
   Abstract »    Full Text »    PDF »
Bidirectional Notch activation represses fusion competence in swarming adult Drosophila myoblasts.
B. Gildor, E. D. Schejter, and B.-Z. Shilo (2012)
Development 139, 4040-4050
   Abstract »    Full Text »    PDF »
Notch signalling in smooth muscle cells during development and disease.
C. Fouillade, M. Monet-Lepretre, C. Baron-Menguy, and A. Joutel (2012)
Cardiovasc Res 95, 138-146
   Abstract »    Full Text »    PDF »
bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation.
E. Zacharioudaki, S. S. Magadi, and C. Delidakis (2012)
Development 139, 1258-1269
   Abstract »    Full Text »    PDF »
The transcriptional corepressor SMRTER influences both Notch and ecdysone signaling during Drosophila development.
B. W. Heck, B. Zhang, X. Tong, Z. Pan, W.-M. Deng, and C.-C. Tsai (2012)
Biology Open 1, 182-196
   Abstract »    Full Text »    PDF »
CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster.
E. Domanitskaya and T. Schupbach (2012)
J. Cell Sci. 125, 399-410
   Abstract »    Full Text »    PDF »
The transcriptional corepressor SMRTER influences both Notch and ecdysone signaling during Drosophila development.
B. W. Heck, B. Zhang, X. Tong, Z. Pan, W.-M. Deng, and C.-C. Tsai (2012)
Biology Open
   Abstract »    Full Text »    PDF »
Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila.
Y. Song and B. Lu (2011)
Genes & Dev. 25, 2644-2658
   Abstract »    Full Text »    PDF »
Notch signaling: simplicity in design, versatility in function.
E. R. Andersson, R. Sandberg, and U. Lendahl (2011)
Development 138, 3593-3612
   Abstract »    Full Text »    PDF »
The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis.
K. C. Barry, M. Abed, D. Kenyagin, T. R. Werwie, O. Boico, A. Orian, and S. M. Parkhurst (2011)
Development 138, 1759-1769
   Abstract »    Full Text »    PDF »
Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells.
D. M. Vallejo, E. Caparros, and M. Dominguez (2011)
EMBO J. 30, 756-769
   Abstract »    Full Text »    PDF »
Specificity of Notch pathway activation: Twist controls the transcriptional output in adult muscle progenitors.
F. Bernard, A. Krejci, B. Housden, B. Adryan, and S. J. Bray (2010)
Development 137, 2633-2642
   Abstract »    Full Text »    PDF »
Reprogramming of T Cells to Natural Killer-Like Cells upon Bcl11b Deletion.
P. Li, S. Burke, J. Wang, X. Chen, M. Ortiz, S.-C. Lee, D. Lu, L. Campos, D. Goulding, B. L. Ng, et al. (2010)
Science 329, 85-89
   Abstract »    Full Text »    PDF »
Drosophila adult muscle precursors form a network of interconnected cells and are specified by the rhomboid-triggered EGF pathway.
N. Figeac, T. Jagla, R. Aradhya, J. P. Da Ponte, and K. Jagla (2010)
Development 137, 1965-1973
   Abstract »    Full Text »    PDF »
The H3K27me3 Demethylase dUTX Is a Suppressor of Notch- and Rb-Dependent Tumors in Drosophila.
H. M. Herz, L. D. Madden, Z. Chen, C. Bolduc, E. Buff, R. Gupta, R. Davuluri, A. Shilatifard, I. K. Hariharan, and A. Bergmann (2010)
Mol. Cell. Biol. 30, 2485-2497
   Abstract »    Full Text »    PDF »
The cytolinker Pigs is a direct target and a negative regulator of Notch signalling.
M. K. Pines, B. E. Housden, F. Bernard, S. J. Bray, and K. Roper (2010)
Development 137, 913-922
   Abstract »    Full Text »    PDF »
Drosophila Hey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesis.
M. Monastirioti, N. Giagtzoglou, K. A. Koumbanakis, E. Zacharioudaki, M. Deligiannaki, I. Wech, M. Almeida, A. Preiss, S. Bray, and C. Delidakis (2010)
Development 137, 191-201
   Abstract »    Full Text »    PDF »
Nodal points and complexity of Notch-Ras signal integration.
G. D. Hurlbut, M. W. Kankel, and S. Artavanis-Tsakonas (2009)
PNAS 106, 2218-2223
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882