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Sci. Signal., 27 January 2009
Vol. 2, Issue 55, p. ra1
[DOI: 10.1126/scisignal.2000140]


Editor's Summary

Micromanaging Development
By combining microarray gene expression data with occupancy by a key DNA binding transducer in the Notch pathway, Krejcí et al. set a gold standard for target genes that are regulated directly by Notch. The analysis also reveals incoherent network logic in which Notch signaling activates both positive and negative regulators of several pathways, which may allow Notch to micromanage multiple signaling networks and poise cells for different responses depending on the context. Detailed analysis of several Notch direct target genes in vivo reveals that many of the identified genes participate in regulation of adult muscle progenitors in Drosophila.

Citation: A. Krejcí, F. Bernard, B. E. Housden, S. Collins, S. J. Bray, Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic. Sci. Signal. 2, ra1 (2009).

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