Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 27 January 2009
Vol. 2, Issue 55, p. ra1
[DOI: 10.1126/scisignal.2000140]

RESEARCH

Editor's Summary

Micromanaging Development
By combining microarray gene expression data with occupancy by a key DNA binding transducer in the Notch pathway, Krejcí et al. set a gold standard for target genes that are regulated directly by Notch. The analysis also reveals incoherent network logic in which Notch signaling activates both positive and negative regulators of several pathways, which may allow Notch to micromanage multiple signaling networks and poise cells for different responses depending on the context. Detailed analysis of several Notch direct target genes in vivo reveals that many of the identified genes participate in regulation of adult muscle progenitors in Drosophila.

Citation: A. Krejcí, F. Bernard, B. E. Housden, S. Collins, S. J. Bray, Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic. Sci. Signal. 2, ra1 (2009).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nodal points and complexity of Notch-Ras signal integration.
G. D. Hurlbut, M. W. Kankel, and S. Artavanis-Tsakonas (2009)
PNAS 106, 2218-2223
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882