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Sci. Signal., 27 January 2009
Vol. 2, Issue 55, p. ra1
[DOI: 10.1126/scisignal.2000140]
RESEARCH ARTICLES
Editor's Summary
Micromanaging Development
By combining microarray gene expression data with occupancy by a key DNA binding transducer in the Notch pathway, Krejí et al. set a gold standard for target genes that are regulated directly by Notch. The analysis also reveals incoherent network logic in which Notch signaling activates both positive and negative regulators of several pathways, which may allow Notch to micromanage multiple signaling networks and poise cells for different responses depending on the context. Detailed analysis of several Notch direct target genes in vivo reveals that many of the identified genes participate in regulation of adult muscle progenitors in Drosophila.
Citation: A. Krejcí, F. Bernard, B. E. Housden, S. Collins, S. J. Bray, Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic. Sci. Signal.2, ra1 (2009).
Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme.
A. Terriente-Felix, J. Li, S. Collins, A. Mulligan, I. Reekie, F. Bernard, A. Krejci, and S. Bray (2013)
Development
140, 926-937
|Abstract »|Full Text »|PDF »
Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling.
J. Guiu, R. Shimizu, T. D'Altri, S. T. Fraser, J. Hatakeyama, E. H. Bresnick, R. Kageyama, E. Dzierzak, M. Yamamoto, L. Espinosa, et al. (2013)
J. Exp. Med.
210, 71-84
|Abstract »|Full Text »|PDF »
Notch signaling: simplicity in design, versatility in function.
E. R. Andersson, R. Sandberg, and U. Lendahl (2011)
Development
138, 3593-3612
|Abstract »|Full Text »|PDF »
The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis.
K. C. Barry, M. Abed, D. Kenyagin, T. R. Werwie, O. Boico, A. Orian, and S. M. Parkhurst (2011)
Development
138, 1759-1769
|Abstract »|Full Text »|PDF »
Specificity of Notch pathway activation: Twist controls the transcriptional output in adult muscle progenitors.
F. Bernard, A. Krejci, B. Housden, B. Adryan, and S. J. Bray (2010)
Development
137, 2633-2642
|Abstract »|Full Text »|PDF »
Reprogramming of T Cells to Natural Killer-Like Cells upon Bcl11b Deletion.
P. Li, S. Burke, J. Wang, X. Chen, M. Ortiz, S.-C. Lee, D. Lu, L. Campos, D. Goulding, B. L. Ng, et al. (2010)
Science
329, 85-89
|Abstract »|Full Text »|PDF »
Drosophila adult muscle precursors form a network of interconnected cells and are specified by the rhomboid-triggered EGF pathway.
N. Figeac, T. Jagla, R. Aradhya, J. P. Da Ponte, and K. Jagla (2010)
Development
137, 1965-1973
|Abstract »|Full Text »|PDF »
The H3K27me3 Demethylase dUTX Is a Suppressor of Notch- and Rb-Dependent Tumors in Drosophila.
H. M. Herz, L. D. Madden, Z. Chen, C. Bolduc, E. Buff, R. Gupta, R. Davuluri, A. Shilatifard, I. K. Hariharan, and A. Bergmann (2010)
Mol. Cell. Biol.
30, 2485-2497
|Abstract »|Full Text »|PDF »
The cytolinker Pigs is a direct target and a negative regulator of Notch signalling.
M. K. Pines, B. E. Housden, F. Bernard, S. J. Bray, and K. Roper (2010)
Development
137, 913-922
|Abstract »|Full Text »|PDF »
Drosophila Hey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesis.
M. Monastirioti, N. Giagtzoglou, K. A. Koumbanakis, E. Zacharioudaki, M. Deligiannaki, I. Wech, M. Almeida, A. Preiss, S. Bray, and C. Delidakis (2010)
Development
137, 191-201
|Abstract »|Full Text »|PDF »
Nodal points and complexity of Notch-Ras signal integration.
G. D. Hurlbut, M. W. Kankel, and S. Artavanis-Tsakonas (2009)
PNAS
106, 2218-2223
|Abstract »|Full Text »|PDF »
í et al. set a gold standard for target genes that are regulated directly by Notch. The analysis also reveals incoherent network logic in which Notch signaling activates both positive and negative regulators of several pathways, which may allow Notch to micromanage multiple signaling networks and poise cells for different responses depending on the context. Detailed analysis of several Notch direct target genes in vivo reveals that many of the identified genes participate in regulation of adult muscle progenitors in Drosophila.
