Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Sci. Signal., 27 January 2009
Vol. 2, Issue 55, p. ra2
[DOI: 10.1126/scisignal.2000189]

RESEARCH ARTICLES

Editor's Summary

Blocking mTor Signals
The mammalian target of rapamycin (mTOR), a protein kinase critical to cell growth and proliferation, functions as part of two distinct multiprotein complexes. mTOR signaling is frequently disrupted in cancer; however pharmacological suppression of mTOR complex 1 (mTORC1) signaling has been of limited therapeutic efficacy. Nardella et al. show that, whereas conditional inactivation of mTOR activity (abrogating signaling through both complexes) has little effect in the adult mouse prostate, it markedly suppresses prostate cancer associated with loss of the tumor suppressor PTEN. Thus, mTOR inhibitors that target its catalytic activity may be more effective in cancer therapy than those that specifically inhibit signaling mediated through mTORC1.

Citation: C. Nardella, A. Carracedo, A. Alimonti, R. M. Hobbs, J. G. Clohessy, Z. Chen, A. Egia, A. Fornari, M. Fiorentino, M. Loda, S. C. Kozma, G. Thomas, C. Cordon-Cardo, P. P. Pandolfi, Differential Requirement of mTOR in Postmitotic Tissues and Tumorigenesis. Sci. Signal. 2, ra2 (2009).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mammalian target of rapamycin and the kidney. II. Pathophysiology and therapeutic implications.
W. Lieberthal and J. S. Levine (2012)
Am J Physiol Renal Physiol 303, F180-F191
   Abstract »    Full Text »    PDF »
Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation.
Z. Fang, T. Zhang, N. Dizeyi, S. Chen, H. Wang, K. D. Swanson, C. Cai, S. P. Balk, and X. Yuan (2012)
J. Biol. Chem. 287, 2090-2098
   Abstract »    Full Text »    PDF »
From man to mouse and back again: advances in defining tumor AKTivities in vivo.
D. F. Restuccia and B. A. Hemmings (2010)
Dis. Model. Mech. 3, 705-720
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 21 April 2009.
M. B. Yaffe and A. M. VanHook (2009)
Science Signaling 2, pc8
   Abstract »    Full Text »
The Pharmacology of mTOR Inhibition.
D. A. Guertin and D. M. Sabatini (2009)
Science Signaling 2, pe24
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 03 February 2009.
P. P. Pandolfi and A. M. VanHook (2009)
Science Signaling 2, pc3
   Abstract »    Full Text »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882