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Sci. Signal., 27 January 2009
Vol. 2, Issue 55, p. ra4
[DOI: 10.1126/scisignal.2000014]

RESEARCH ARTICLES

Editor's Summary

An Unexpected Route
Gliomas, the most common and most deadly form of brain tumor, are often associated with increased EGFR signaling. However, at least in part because of additional downstream mutations, most patients fail to respond to drugs that inhibit EGFR. One of the signaling pathways thought to be critical to driving glioma cell proliferation is that linking EGFR to the kinase mTOR. Fan et al. explore EGFR signaling pathways in glioma cells and confirm the importance of signaling between EGFR and mTOR to EGFR-dependent glioma cell proliferation. Unexpectedly, however, they find that the PKC{alpha} plays a key role in the signaling pathway linking EGFR to mTOR, whereas Akt—commonly thought to be a key intermediate in this pathway—does not.

Citation: Q.-W. Fan, C. Cheng, Z. A. Knight, D. Haas-Kogan, D. Stokoe, C. D. James, F. McCormick, K. M. Shokat, W. A. Weiss, EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma. Sci. Signal. 2, ra4 (2009).

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